Clinical Trials Logo

Clinical Trial Summary

This study will use different indices for prediction of NIV failure in ARF patients Evaluation of HACOR score and ROX index for early prediction of NIV failure in patients with ARF. Study value of diaphragmatic dysfunction assessed by ultrasound as tool for prediction of success of NIV in ARF patients. Compare clinical significance of these scoring systems between hypoxemic and hypercapnic RF


Clinical Trial Description

Noninvasive ventilation (NIV) is a useful and safe method to improve gas exchange in patients with acute respiratory failure (ARF) of different etiologies. NIV reduces the work of breathing, improves arterial oxygenation and alveolar ventilation. It is associated with improved survival in the acute care setting (Cabrini L 2015) when compared to conventional oxygen therapy. As NIV offers several major advantages over invasive ventilation (e.g., preserving the ability to swallow, cough, and communicate verbally), it is widely used to avoid intubation. Although NIV nowadays is frequently used, its failure rate remains high (25-59%), indicating that not all patients benefit from this treatment. There is an association between the unsuccessful NIV and the poor outcome has been suggested. Among patients who experience NIV failure, either premature or delayed NIV discontinuation further increases mortality. Thus, identifying the predictors of NIV failure is crucial because of the strong link between failure and poor outcomes. So, researchers woke to make scoring systems that may predict NIV failure, as HACOR and ROX indices. Recently, ultrasonography (US) of the diaphragm as a bedside method is used for evaluation of diaphragmatic function and predicting failure of NIV in acutely ill patients. Up till now there is limited research to support significance of different indices for prediction of NIV failure and need for invasive mechanical ventilation (IMV). ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05850195
Study type Observational
Source Assiut University
Contact Asmaa Razek
Phone 01061855512
Email drasmaarazek85@gmail.com
Status Not yet recruiting
Phase
Start date June 1, 2023
Completion date June 1, 2025

See also
  Status Clinical Trial Phase
Not yet recruiting NCT05756387 - Improving Chronic Nocturnal Noninvasive Ventilation: a Multimodality Approach
Not yet recruiting NCT06259565 - Non-invasive Ventilation and Dexmedetomidine in Critically Ill Adults Phase 3
Completed NCT02973373 - MRI of the Chest Under High Frequency Ventilation N/A
Recruiting NCT06072339 - Optimization of Positive End Expiratory Pressure by Use of Pulmonary Ultrasound for Patients With Blunt Chest Trauma Treated by Non-Invasive Ventilation (Opti-PEP). N/A
Recruiting NCT04054622 - Patient-ventilator Asychrony During Non-invasive Ventilation When COPD Patients Doing Exercise
Completed NCT03859947 - High-flow Nasal Cannula Flow Rates, Severe Bronchiolitis
Completed NCT03149835 - NIV Reduces CBF in COPD Patients Without Cognitive Function N/A
Recruiting NCT04036175 - Comparison of Patient Work of Breathing and Tidal Volumes With High Flow Nasal Cannula Oxygen Therapy and NIV (Non-Invasive Ventilation) After Extubation in the ICU. N/A
Recruiting NCT02712190 - Evaluation of Prolonged Apnea Supported by High Frequency Non-invasive Ventilation. N/A
Not yet recruiting NCT05435183 - Effect of Noninvasive High Frequency Oscillatory Ventilation on Improving Carbon Dioxide Clearance in AECOPD Patients N/A
Recruiting NCT05796297 - Clinical Impact of Patient-ventilator Asynchrony
Not yet recruiting NCT05448417 - Exploration of Non-invasive High-frequency Oscillations in Human-machine Asynchrony in Healthy Subjects N/A
Completed NCT05031650 - Open Lung Strategy During Non-Invasive Respiratory Support of Very Preterm Infants in the Delivery Room N/A
Completed NCT03130361 - Wearable Noninvasive Positive Pressure Ventilation Device in COPD N/A
Completed NCT04178694 - The Influence of Non-invasive Ventilation on Metabolism in Healthy Volunteers N/A
Not yet recruiting NCT05721833 - Effect of Noninvasive High Frequency Oscillatory Ventilation on Improving CO2 Clearance in COPD Patients N/A
Not yet recruiting NCT05706467 - The Difference Between Non-invasive High-frequency Oscillatory Ventilation and Non-invasive Continuous Airway Pressure Ventilation in COVID-19 With Acute Hypoxemia N/A
Recruiting NCT01961245 - Effects of Nocturnal Non-invasive Ventilation on Energy Expenditure in Patients With Severe Chronic Obstructive Pulmonary Disease N/A
Recruiting NCT03978221 - Tissue Doppler Ultrasound During Spontaneous Breathing and Non-invasive Ventilation in the Post-extubation Period. N/A
Completed NCT04884828 - Asynchronies in NIV With External Gas