A Phase I Study of ZN-d5 in Chinese Subjects With Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma Clinical Trial

Official title:

A Phase I Dose Escalation Study of ZN-d5 Monotherapy in Chinese Subjects With Non-Hodgkin Lymphoma

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT05127811
• Other study ID #: d5ZTCN100
• Status: Terminated
• Phase: Phase 1
• Start date: October 21, 2021
• Est. completion date: May 26, 2023

Study information

• Verified date: May 2023
• Source: Zentera Therapeutics HK Limited
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

A phase I dose-escalation, open-label, multicenter study to assess the safety, tolerability, clinical activity, and pharmacokinetics (PK) of ZN-d5 in Chinese subjects with non-Hodgkin lymphoma (NHL).

Description:

For the Phase I dose escalation study of ZN-d5, it is planned that after the starting dose, subsequent dose assignments will be made by means of a model-assisted design, until the MTD or RP2D is determined in the Chinese population.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 8
• Est. completion date: May 26, 2023
• Est. primary completion date: May 26, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. NHL, relapsed from or refractory to at least 2 prior lines of systemic therapy (excluding radiotherapy and surgery); subjects must have failed or not be candidates for available standard therapy expected to provide clinical benefit.

2. Female subjects of childbearing potential must have a negative serum pregnancy test and agree to use contraception while on study.

3. Eastern Cooperative Oncology Group performance status = 1.

4. Adequate blood and other organ function, defined by the following criteria:

1. Neutrophil count (ANC) = 1.0 × 109/L.

2. Platelet count = 75 × 109/L at least 3 days after platelet transfusion (= 50 × 109/L permitted if the bone marrow is > 50% lymphoma cells).

3. Hemoglobin = 8.0 g/dL.

4. Coagulation parameters = 1.5 × upper limit of normal (ULN).

5. Liver enzymes = 3 × ULN and total bilirubin = 1.5 × ULN.

6. Creatinine clearance = 60 mL/min.

Exclusion Criteria:

1. Received any of the following prior to start of ZN-d5 treatment:

1. Systemic administration of antineoplastic agents (including investigational agents) within the shorter of 28 days or 5 half-lives.

2. Major surgery within 28 days.

3. Radiotherapy within 14 days.

4. Autologous or allogeneic stem cell transplantation within 60 days, or receiving immunosuppression for active graft-versus-host disease.

5. Use of strong CYP3A4 inhibitors, P-gp inhibitors or QT prolonging agents within 5 half-lives, or potent or moderate CYP3A4 inducers within 14 days.

2. Ongoing and clinically significant non-hematologic toxicity related to prior antineoplastic therapy.

3. Presence of major cardiovascular system diseases (including QTcF > 480 msec).

4. Positive serology for human immunodeficiency virus, hepatitis B, or hepatitis C unless no detectable hepatitis B or C viral load.

5. Unable to take oral drugs or presence of severe gastrointestinal abnormalities.

6. Active and uncontrolled clinically significant infection.

7. Other active systemic malignancy or other severe, unstable, or poorly controlled acute or chronic medical conditions.

8. Prior treatment with venetoclax or other BCL-2 inhibitors.

9. Primary or secondary CNS lymphoma.

10. Presence of post-transplant lymphoproliferative disease, Burkitt's lymphoma, Burkitt-like lymphoma, T lymphoblastic lymphoma and T lymphoblastic acute leukemia.

Related Conditions & MeSH terms

• Lymphoma
• Lymphoma, Non-Hodgkin
• Non-Hodgkin Lymphoma

Intervention

Drug:
• ZN-d5
BION design

Locations

Country	Name	City	State
China	BeiJing Cancer Hospital	BeiJing	Beijing
China	Sun Yan Set University Cancer Center	Guangzhou	Guangdong
China	Fudan University Shanghai Cancer Hospital	Shanghai	Shanghai

Sponsors (1)

Lead Sponsor	Collaborator
Zentera Therapeutics HK Limited

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Safety monitoring	Incidence and severity of adverse events (AEs), graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) version 5.0	until 30 days after the last dose of study drug
Primary	DLT	Dose-limiting toxicities (DLTs) observed in DLT evaluable subjects	at the end of Cycle 1
Secondary	Effacy Evaluation	Efficacy as defined by the 2014 Lugano response criteria	up to 24 months
Secondary	Maximum Plasma Concentration [Cmax]	Plasma PK parameters of ZN-d5	up to 24 months