Non-hodgkin Lymphoma Clinical Trial
Official title:
Randomized Phase II Multi-center Trial of Busulfan, Etoposide, and Cyclophosphamide Versus Busulfan, Etoposide, and Melphalan as Conditioning Therapy for Autologous Stem-cell Transplantation(ASCT) in Patients With Non-Hodgkin's Lymphoma
The investigators developed a protocol comparing busulfan/cyclophosphamide/etoposide (BuCE) and busulfan/melphalan/etoposide (BuME) regimen as a conditioning for high-dose therapy (HDT) in the patients with high risk or relapsed Non-Hodgkin's Lymphoma (NHL).
Intravenous busulfan containing regimens as conditioning regimen have been used for both
allogeneic and autologous stem cell transplantation in patients with hematologic and
non-hematologic malignancies.
The investigators have previously studied that conditioning regimen of i.v.
busulfan/melphalan/etoposide (BuME) was well tolerated and effective in patients with
relapsed or high risk NHL. And busulfan/cyclophosphamide/etoposide (BuCE) conditioning
regimen has been extensively utilized in ASCT for NHL.
Therefore, based on the encouraging results, the investigators will conduct a randomized
phase II multicenter trial of BuCE versus BuME as conditioning therapy for ASCT in patients
with NHL.
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