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Clinical Trial Summary

The development of Immune Checkpoint Blockade (ICB) is a revolution in medical oncology as ICB have changed the standard treatments of several metastatic tumor types. However, the response rate to ICB is low, and the biological bases for this response heterogeneity are poorly understood. In the frame of Immunosup study, we will collect blood (at baseline, post infusion of ICB n°2/4/8 and at progression) and tumor samples (optional: at baseline and progression) from patients with locally advanced or metastatic cancer, treated with ICB, in order to determine if the dynamics of immunosuppressive actors (MDSC, TReg, Immunosuppressive cytokines) predicts response to these immunotherapies.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03595813
Study type Interventional
Source Institut Paoli-Calmettes
Contact
Status Active, not recruiting
Phase N/A
Start date January 29, 2018
Completion date July 2025

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