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Liver Health and Metabolic Function in People With Obesity

Non-Alcoholic Fatty Liver Disease Clinical Trial

Official title:
Liver Health and Metabolic Function in People With Obesity

Clinical Trial Summary

This project aims to determine the effect of significant weight loss on rates on hepatic fibrogenesis in people with obesity.

Clinical Trial Description

Non-alcoholic fatty liver disease (NAFLD) affects approximately 70% of those with obesity and if left untreated can progress to cirrhosis and liver failure. NAFLD stages progress from the stage of simple steatosis to steatohepatitis, and fibrosis The stage of NAFLD is currently best determined using histology from a liver biopsy, however this provides a static depiction of the state of the liver. Therefore This project aims to determine fibrogenesis in the liver of obese humans in vivo, before and after weight loss. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03701828
Study type Interventional
Source Washington University School of Medicine
Contact
Status Enrolling by invitation
Phase N/A
Start date February 1, 2019
Completion date November 1, 2024
View Details
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