Nodular Goiter Clinical Trial
Official title:
Comparison of Different Doses of Remifentanil on Postoperative Pain in Patients Undergoing Thyroidectomy: a Prospective, Double-blinded Randomized Control Trial
Extensive clinical studies have shown that intraoperative infusion high dose of remifentanil (0.2ug/kg/min) induced postoperative hyperalgesia. Recent experimental study however suggests that higher dose of remifentanil may attenuate postoperative hyperalgesia. Thus, the present study is designed as a "proof of principle" study and hypothesizes that higher dose of remifentanil may reduce postoperative pain in patients.
Status | Recruiting |
Enrollment | 60 |
Est. completion date | |
Est. primary completion date | March 2013 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 60 Years |
Eligibility |
Inclusion Criteria: - ASA Grade I or II - Age 18-60 years old - BMI<35, Exclusion Criteria: - do not consent, - Chronic pain, - used pain killer, - undergoing operation previously - diabetes or the other diseases affecting the sensory. - difficult intubation; - unexpected surgical complication such as bleeding; - psychiatric disorders; - drug or alchohol abuse |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
China | Department of Anesthesiology, The Second Xiangya Hospital | Changsha | Hunan |
Lead Sponsor | Collaborator |
---|---|
Central South University |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | consumption of morphine postoperatively | 24 hours | Yes | |
Primary | Changes of sensory threshold from baseline to postoperative 24hours | Quantitative sensory threshold in the remote uninjured site (here, the inner forearm) is commonly used to examine the occurrence of postoperative hyperalgesia. The present study will examine the mechanical threshold in two different doses of remifentanil to determine whether high dose of remifentanil induces hyperalgesia | 24 hour | Yes |
Secondary | visual analogue score (VAS) | VAS is widely used to assess postoperative pain. It will be divided as 10 points. Zero refers to no pain and ten refers to extremely pain. Based on this way, we can know the difference of postoperative pain in these two different groups. | 24 hours | Yes |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
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