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Combination Nicotine Patch / Lorcaserin for Smoking Cessation — LorNic  

Nicotine Dependence Clinical Trial

Official title:
Combination Nicotine Patch / Lorcaserin for Smoking Cessation

Clinical Trial Summary

This study plans to compare the efficacy of the nicotine patch / lorcaserin combination treatment vs. the nicotine patch alone in terms of leading to a reduction in smoking behavior and withdrawal symptoms.

Clinical Trial Description

This study proposes to investigate the potential efficacy of a combination of two FDA-approved agents, nicotine patch and lorcaserin, for smoking cessation treatment. The nicotine patch which provides a sustained low dose of nicotine is a nicotine receptor agonist. Lorcaserin, a serotonin 5-hydroxytryptamine receptor 2C (5-HT2C) agonist, is a drug that is FDA-approved for weight loss, and has also recently been shown to be efficacious for smoking cessation. Given that these drugs act through distinct mechanisms it is hoped that the combination will prove more efficacious than either drug alone. It is also hypothesized that the combination will reduce weight gain commonly seen after smoking cessation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02906644
Study type Interventional
Source Duke University
Contact
Status Completed
Phase Phase 2
Start date November 8, 2016
Completion date October 18, 2018
View Details
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