Treatment for Nicotine Addiction in Women

Status Completed

Clinical Trial Summary

The purpose of this study is to use a medication tolcapone and or placebo to test if the symptoms of nicotine withdrawal lessens , and or changes in smoking urges, and mental reasoning in female smokers over a 72 hour period.

Clinical Trial Description

The proposed trail will be use a double-blind, placebo-controlled design to conduct the first randomized controlled trial of the COMT inhibitor, tolcapone, in nicotine dependent women. This study will determine if tolcapone is superior to placebo by attenuation the severity of nicotine withdrawal and smoking urges during short-term abstinence. Withdrawal severity will be assessed by a self-report scale and cognitive assessment, including a sustained-attention task. Smoking urges will be assessed by a self-report scale. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02448654
Study type	Interventional
Source	Yale University
Contact
Status	Completed
Phase	N/A
Start date	October 23, 2015
Completion date	June 30, 2019

View Details

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