Nicotine Dependence Clinical Trial
Official title:
Pilot Study of Transcranial Direct Current Stimulation (tDCS) as a Smoking Cessation Treatment for Nicotine Dependent Smokers
The purpose of this study is to determine the effectiveness of transcranial direct current stimulation (tDCS) plus nicotine patch as a viable smoking cessation program for nicotine dependent smokers.
BACKGROUND: Transcranial direct current stimulation (tDCS) is a form of non-invasive brain
stimulation that involves the application of brief weak electric current to the scalp. tDCS
may induce neuroplasticity, thereby engaging some of the same systems that figure
prominently in the pathological neuroplasticity caused by addictive drugs.
OBJECTIVE: To assess whether tDCS delivered along with nicotine patch reliably increases a)
quit rates, b) duration of abstinence, and c) percentage of participants abstinent at
follow-up.
METHOD: Active (20min; 2mA) and sham (30sec; 2mA) stimulation will be applied to the
dorsolateral prefrontal cortex (DLPFC) in both cerebral hemispheres.
HYPOTHESES:
1. Active tDCS (20-min; 2 mA) will increase abstinence in a standard smoking cessation
protocol relative to a sham procedure.
2. The benefits of active left anodal stimulation (anode-left/cathode-right) to the DLPFC
will be greater than of active tDCS in the reverse configuration
(cathode-left/anode-right).
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment
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