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Pioglitazone for Heroin and for Nicotine Dependence

Nicotine Dependence Clinical Trial

Official title:
Effects of Pioglitazone, a PPARĪ³ Agonist, on the Abuse Liability of Heroin and of Nicotine

Clinical Trial Summary

The goal of the proposed research is to improve the effectiveness of treatments for opioid and for nicotine dependence by testing a novel pharmacological strategy. Specifically, pioglitazone, a peroxisome proliferator-activated gamma receptor (PPARĪ³) agonist, will be used as an adjunct to agonist-based treatment.

Clinical Trial Description

Although treatments for opioid and for nicotine dependence exist, these medications are not universally effective as many patients are unable to stop using or relapse rapidly, suggesting that treatment with a single agent alone is insufficient to facilitate cessation of use in many patients. Targeting additional pathways that may contribute to the maintenance of drug-taking behaviors or relapse may be a more effective strategy to treat individuals resistant to first-line approaches. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01395797
Study type Interventional
Source New York State Psychiatric Institute
Contact
Status Terminated
Phase Phase 1/Phase 2
Start date March 2011
Completion date June 2014
View Details
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