NF1 Clinical Trial
Official title:
Natural History of Plexiform in Neurofibromatosis Type I
Background:
-Plexiform neurofibromas in patients with NF1 are a significant cause of morbidity but little
is known about the natural history of these lesions.
Objectives:
- The purpose of this study is to monitor the natural history of plexiform neurofibromas
and to evaluate the usefulness of volumetric MRI tumor measurements in this disease.
- Other goals of the study are to provide a body of normative data on the growth rate of
plexiform neurofibromas and to establish a tissue repository and pathology review center
to allow future studies of the pathogenesis of neurofibromas and clinical trials of
potential therapeutic agents.
Design
- This study is coordinated by Dr. Bruce Korf, and was initiated when he was at the Partners
Center for Human Genetics, Boston, MA.
Background:
-Plexiform neurofibromas in patients with NF1 are a significant cause of morbidity but little
is known about the natural history of these lesions.
Objectives:
- The purpose of this study is to monitor the natural history of plexiform neurofibromas
and to evaluate the usefulness of volumetric MRI tumor measurements in this disease.
- Other goals of the study are to provide a body of normative data on the growth rate of
plexiform neurofibromas and to establish a tissue repository and pathology review center
to allow future studies of the pathogenesis of neurofibromas and clinical trials of
potential therapeutic agents.
Design
- This study is coordinated by Dr. Bruce Korf, and was initiated when he was at the Partners
Center for Human Genetics, Boston, MA.
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