Nevi Clinical Trial
Official title:
BRAF and Nevi.Nevi Are Common Benign Pigmented Tumors of the Skin. Mutations in So-called BRAF and NRAS Genes Genes Appear to be Initiating Events Responsible for the Formation of Nevi.
This project is a multicenter study in which we will investigate a dual concept of
nevogenesis. Study location is the Department of Dermatology at the Medical University of
Graz in collaboration with centers in Austria (Vienna), Italy (Naples, Benevento, Modena),
Spain (Barcelona) and the United States (New York).
The hypothesis is that small congenital melanocytic nevi (CMN), "early" acquired melanocytic
nevi in childhood (AMN) and dermal nevi, all dermatoscopically characterized by globular
pattern, belong to the same spectrum of genetically determined melanocytic proliferations
that develop due to endogenous pathways, in contrast to "true" acquired melanocytic nevi,
dermatoscopically showing reticular pattern, that develop due to exogeneous factors such as
UV-exposure.
The investigations to this study will verify whether small CMN, "early" AMN and dermal nevi, characterized by globular pattern differ in their genetic alterations compared to reticular typed nevi. It will be expected that globular typed nevi and eventually dermal nevi lack B-RAF mutations whereas reticular nevi show alterations in the B-RAF gene. Study location: Graz ;
Allocation: Non-Randomized, Endpoint Classification: Bio-availability Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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