Clinical Trials Logo
  1. Home
  2. Neutropenia, Febrile
  3. NCT05926063

Stopping Antibiotics After 3 Days for the Treatment of High-risk FEbrile Neutropenia — SAFE  

Neutropenia, Febrile Clinical Trial

Official title:
Stopping Antibiotics After 3 Days for the Treatment of FEbrile Neutropenia in Haematology Patients (SAFE Study): a Randomized Open-label Non-inferiority Trial

Clinical Trial Summary

The goal of this clinical trial is to compare a short course of antibiotics in patients in whom no bacterial infection is found with the current "golden standard": long-term antibiotic treatment in adult hematology patients who develop neutropenic fever. The main question it aims to answer is: whether the short-term treatment is equally safe for patients, hence the name 'SAFE study'. Participants will be randomly assigned (randomized) to one of two treatment options once they develop neutropenic fever: short-term or long-term antibiotic treatment. An additional blood sample, urine sample and stool sample will be collected. Researchers will compare the short-term and the long-term antibiotic treatment groups to see if the short treatment is equally safe as the long-term treatment group.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05926063
Study type Interventional
Source Universitaire Ziekenhuizen KU Leuven
Contact Robina Aerts, MD
Phone +32 16 34 48 77
Email robina.aerts@kuleuven.be
Status Recruiting
Phase Phase 4
Start date February 26, 2024
Completion date July 2026
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT04637464 - Early Termination of Empirical Antibiotics in Febrile Neutropenia in Children With Cancer N/A
Completed NCT03511820 - A Post Marketing Surveillance Study of Lipo-AB® (Amphotericin B) in Neutropenic Patients With Persistent Fever
Not yet recruiting NCT04260230 - Remote Monitoring of Patients at Risk of Sepsis N/A
Completed NCT04187755 - Cefepime vs Ceftazidime as Empirical Therapy for Neutropenic Fever Phase 4
Completed NCT03217721 - Antibiotics Management of Septic Neutropenic Patients in the Intensive Care Unit N/A
Completed NCT04669418 - Host RNA Signature in Children With Cancer and Infection
Recruiting NCT04938206 - DIStinguishing ChildrEn at Low Risk of Severe infectioN in Case of Febrile Neutropenia-7: Impact Study of a Clinical Decision Rule N/A
Terminated NCT03003273 - Early Stoppage Versus Continuation of Antimicrobial Therapy in Low Risk Pediatric Cancer Patients With Febrile Neutropenia, Before Recovery of Counts: -DALFEN Study Phase 3
Not yet recruiting NCT05852249 - Investigation of the Usability of Neutrocheck Amongst Healthy Volunteers and Healthcare Professionals.
Withdrawn NCT05061654 - CEFtolozane-Tazobactam for the Empiric Anti-bacterial Treatment of Neutropenic Fever in Hematology Patients Phase 4
Recruiting NCT02474550 - Multicenter Prospective Registry Study of Diffuse Large B Cell Lymphoma N/A