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Clinical Trial Summary

Nitrous oxide (N2O) is a colorless, flammable, analgesic gas used in surgery and dentistry. The consumption of N2O has increased among young French people aiming to relax because of its short-lived neuropsychological effect (euphoria, depersonalization, analgesia) and its wide availability on the market. It can be responsible in case of prolonged use and overdose of a vitamin B12 deficiency with possible neuropsychiatric complications: sensitivomotor neuropathy, myelopathy, behavioral and cognitive disorders of acute or sub-acute installation. N2O inhibits the activitý of methionine synthase, decreases the activitý of methylmalonyl-CoA mutase leading to vitamin B12 deficiency but in addition to the interference with vitamin B12 metabolism there seems to be a direct toxicity of N20. Myelin alteration was the typical electromyography finding but new axonal profiles were also described. Since myelopathy affects both the posterior and lateral cords, combined spinal cord sclerosis is the most common location of injury associated with N2O intoxication.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05469321
Study type Observational
Source Centre Hospitalier Universitaire de Nimes
Contact Ioana Maria ION
Phone 06 22 920361
Email ioanamaria@chu-nimes.fr
Status Recruiting
Phase
Start date August 22, 2022
Completion date December 2024

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