Neuropathic Pain Clinical Trial
Official title:
Effect of Pregabalin in Patients With Radiotherapy-Related Neuropathic Pain: a Randomized, Double-blind, Placebo-controlled Trial
Rationale: Pregabalin is effective on radiotherapy-related neuropathic pain. Purpose: This randomized, double-blind, placebo-controlled trial aims to investigate the effect and safety of pregabalin in treating radiotherapy-related neuropathic pain.
Radiotherapy for cancer is associated with peripheral neuropathies, especially with brachial
plexus neuropathy and trigeminal neuralgia, which included painful sensation that are
described as burning, aching, spasm, or tingling. Though there is some recommendation about
neuropathic pain, there is no definite drug which is recommended for radiotherapy-related
neuropathic pain.
Pregabalin, a central nervous system(CNS)-active compound, is an analog of the
neurotransmitter gamma-aminobutyric acid. It has been proved an effective treatment for
diabetic peripheral neuropathy and postherpetic neuralgia in previous clinical trials. This
study plans to evaluate the efficacy of pregabalin versus placebo for relieving
radiotherapy-related peripheral neuropathic pain, and assessed its safety.
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