Neuropathic Pain Clinical Trial
Official title:
A Double Blind, Active Placebo Controlled Crossover Trial of the Antinociceptive Effect of Smoked Marijuana on Subjects With Neuropathic Pain; Correlation With Changes in Mood, Cognition, and Psychomotor Performance
To determine if smoking marijuana will reduce neuropathic pain without causing too much drowsiness or feeling "too dopey".
The case for marijuana's medical use for pain is primarily from experimental studies with
normal subjects, which have yielded conflicting results. Experimental subjects have been
shown to have significant dose-dependant antinociception effect that is not reversed by
opioid antagonism. In contrast to this positive antinociceptive effect, other experiments
demonstrated hyperalgesic activity and probably enhancement of the perception of pain upon
acute exposure in chronic users of marijuana.
In addition to studying spontaneous pain antinociception, it would be useful to evaluate the
response to marijuana following evoked pain. Such evoked pain is produced by stimulation of
the skin that is normally not noxious.
Because of the potential side effects of marijuana administration, one of the aims of the
present study is to analyze inter-individual variability and the occurrence of
dose-dependant analgesia of marijuana with an eye on defining tolerable dosing in clinical
neuropathic pain syndromes.
Comparisons: Neuropathic and experimentally induced pain scores will be compared after the
administration of escalating doses of low, high, and placebo marijuana cigarettes as
provided by the National Institutes on Drug Abuse (NIDA).
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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