Neuromuscular Diseases Clinical Trial
Official title:
Impact of the Pre-phonatory Inspiratory Volume on the Speech Quality of Neuromuscular Patients Dependent on Non-invasive Ventilation
We want to demonstrate that modifications of the ventilation parameters are liable to improve the different characteristics of phonation (duration, intensity, prosody..) in neuromuscular patients who are dependent on non invasive ventilation.
Speech and communication quality depend on respiration efficiency. The respiratory
involvement observed in neuromuscular disorders can impair speech quality in patients, while
the underlying disease may also contribute to alter phonation.
Nowadays, the first line treatment of neuromuscular chronic neuromuscular respiratory failure
is noninvasive ventilation (NIV). With disease progression, it is used with increasingly
duration during daytime. In that situation, mouthpiece ventilation is preferred as it allows
efficient ventilation while being more comfortable for patients who can chose when they want
to be ventilated. However, in that situation, patients do not receive ventilatory support
while they are speaking which puts them in a less favorable situation for speech. We think
that pre-phonation inspiratory volume is an essential part of speech quality. Without
mechanical ventilation, this volume is reduced as a consequence of respiratory failure but it
is liable to increase significantly if the patient used the volume delivered by the
ventilator .
We believe that phonation is improved by NIV by applying specific ventilation parameters in
patients dependant on mechanical ventilation. The modification could be used by neuromuscular
patients to improve speech quality; the patients would then be able to use their usual
ventilatory support to improve phonation and modulation of their speech.
In this crossover open labelled, randomised study, done in a single center (home ventilation
unit of the referral center of Hospital Raymond Poincaré HUPIFO (University Hospital of
Western Paris and Ile de France) (Garches, France)), phonation characteristics will be
studied in 3 situations (during spontaneous breathing without ventilatory support, with the
usual NIV parameters, with speech-specific NIV parameters) during which speech trials will be
performed.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT03548779 -
North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2
|
N/A | |
Completed |
NCT04435093 -
Digitalization Playful Module of Motor Function Measure Assessment for Children With Neuromuscular Disorders, MFM-Play Pilot Study.
|
||
Not yet recruiting |
NCT04089696 -
Validation of the "ExSpiron©" in Patients With ALS
|
N/A | |
Not yet recruiting |
NCT05785546 -
Elaboration of a Pronostic Score of Changes on Wheelchair's Seating System
|
||
Completed |
NCT01313325 -
Hippotherapy to Improve the Balance of Children With Movement Disorders
|
N/A | |
Recruiting |
NCT04098094 -
Outcomes of RV Dysfunction in Acute Exacerbation of Chronic Respiratory Diseases
|
||
Active, not recruiting |
NCT05070624 -
The Peer Support Study
|
N/A | |
Completed |
NCT04729920 -
Home Use of Mechanical Insufflation/Exsufflation Devices in Neuromuscular Diseases
|
||
Recruiting |
NCT04581577 -
Perceptions of the Clinical and Psychosocial Impact of Covid-19 in Patients With Neuromuscular and Neurological Disorders
|
||
Completed |
NCT06428864 -
Effect of the Use of a 3D Scanner Application on a Smartphone to Mold Garchois Orthotic Device in Neuromuscular Diseases Patients With Scoliosis
|
||
Enrolling by invitation |
NCT05539456 -
Reliability and Validity of the Turkish Version of the PedsQL 3.0 Neuromuscular Module for 2-to 4- Year-old
|
||
Completed |
NCT05353738 -
Efficacy of Vaccination Against COVID-19 in Patients Presenting a Neuromuscular Disease With Severe Amyotrophy
|
||
Recruiting |
NCT04541602 -
Detection of Neuromuscular Complications in Critically Ill Patients
|
||
Completed |
NCT03394859 -
Electronic Medical Records and Genomics (eMERGE) Phase III
|
||
Enrolling by invitation |
NCT05099107 -
Changes of Motor Function Tests in Congenital Myopathy Subjects Treated With Oral Salbutamol as Compared to no Treatment
|
N/A | |
Completed |
NCT05070910 -
NDT Effectiveness Study
|
N/A | |
Recruiting |
NCT04100993 -
Multisystem and Autonomic Complications of NMD on Long-term NIV
|
||
Recruiting |
NCT04986059 -
Effects of Pre-event Massage on Muscle Activity
|
N/A | |
Completed |
NCT01022931 -
Epidemiology and Clinical Presentation of H1N1 Infection in Children in Geneva
|
N/A | |
Terminated |
NCT03353064 -
Telemedicine for Improving Outcome in Inner City Patient Population With Hypercapneic Respiratory Failure
|
N/A |