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Long-Term Effect of LIAM on Respiratory Performance in NIV Patients Suffering From Neuromuscular Disease — LIAM  

Neuromuscular Disease Clinical Trial

Official title:
Long-Term Effect of LIAM (Lung Insufflation Assist Maneuver) on Respiratory Performance in Non-invasive Ventilated Patients Suffering From Neuromuscular Disease

Clinical Trial Summary

The long-term effect of LIAM (Lung Insufflation Assist Maneuver) on respiratory performance in home non-invasively ventilated (NIV) patients suffering from neuromuscular disease will be assessed in a prospective, randomized, cross over, open label study

Clinical Trial Description

In advanced neuromuscular disorders, respiratory complications represent the main cause of morbidity and mortality. Beside chronic respiratory insufficiency, necessitating a ventilatory support, mostly performed by non-invasive ventilation (NIV), cough is impaired due to the muscle weakness, and respiratory physiotherapy becomes an essential part of the management.

Various techniques have been proposed to improve lung recruitment and cough in neuromuscular patients. The assisted techniques based on a positive pressure insufflation maneuver have shown an improvement in physiological variables on the short term, but there is to date no good-quality prospective study allowing to evaluate the long term efficacy of mechanical cough assistance devices in neuromuscular patients.

We designed a randomized, cross over, open label study to assess the long-term effect of LIAM (Lung Insufflation Assist Maneuver) on respiratory performance in NIV patients suffering from neuromuscular disease. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02288299
Study type Interventional
Source Centre d'Investigation Clinique et Technologique 805
Contact David Orlikowski, MD, PhD
Phone +33(0)147107777
Email david.orlikowski@rpc.aphp.fr
Status Recruiting
Phase N/A
Start date October 29, 2015
Completion date December 31, 2021
View Details
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