Subtotal Resection of Large Acoustic Neuromas With Possible Stereotactic Radiation Therapy

Neuroma, Acoustic Clinical Trial

Official title: Multicenter Prospective Analysis of Treatment Outcome in Patients With Large Acoustic Neuromas

Status Completed

Clinical Trial Summary

The investigators study is to investigate safety and efficacy of performing a planned incomplete removal of large acoustic neuroma tumors to decrease surgical morbidity and yet avoid tumor recurrence by post-operative radiation therapy.

Clinical Trial Description

The current standard treatment of a large tumor of the balance nerve (acoustic neuroma or vestibular schwannoma) is surgical resection. Complete removal of such tumor is associated with significant risks of hearing loss and facial paralysis whereas incomplete removal of the tumor is associated with significant risks of regrowth. Stereotactic radiation is a well accepted therapy aiming at stopping the growth of smaller acoustic neuromas before their sizes become large enough to cause problems. The purpose of our study is to determine whether the combination of subtotal resection followed by stereotactic radiation of the remnant can control large acoustic neuromas without the significant risks associated with complete resection. ;

Related Conditions & MeSH terms

• Neuroma
• Neuroma, Acoustic

• NCT number: NCT01129687
• Study type: Observational
• Source: Stanford University
• Status: Completed
• Start date: March 2005
• Completion date: May 8, 2022