Lorazepam Effects on Neuroimaging Measures

Status Withdrawn

Clinical Trial Summary

This within-subject, double blind, randomized controlled study will investigate the effects of a widely used benzodiazepine (BZD), lorazepam, on various neuroimaging measures. The investigators will be assessing the relationship of lorazepam to resting state functional connectivity and other neuroimaging measures. Specifically, the investigators will be using a pre-identified metric, the striatal connectivity index (SCI), (Sarpal et al. 2015, 2016), a prognostic biomarker of treatment response assessing the connectivity between regions of the striatum and the cortex. The investigators hypothesize that lorazepam administration will be associated with greater SCI values compared with placebo administration; consistent with previous work suggesting short-acting benzodiazepines increase functional connectivity across brain networks.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04671836
Study type	Interventional
Source	Northwell Health
Contact
Status	Withdrawn
Phase	Early Phase 1
Start date	January 2022
Completion date	December 2022

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02972853` - Mindful Self-Regulation fMRI Pilot Study	N/A
Completed	`NCT02879565` - Families Expectations and Hope Raised by an Evaluation of Consciousness in Patients in a Vegetative State	N/A
Recruiting	`NCT03893006` - Vehicle Automation Impact on Drivers	N/A
Active, not recruiting	`NCT02826733` - Evaluation of the Implementation of the Hemispheric Dominance During Development
Completed	`NCT03531580` - Comparing Brain Images Before and After MRI-upgrade - TimFit Upgrade Study	N/A
Completed	`NCT02959489` - Risk Evaluation and Education for Alzheimer's Disease - the Study of Communicating Amyloid Neuroimaging (REVEAL-SCAN)	N/A
Completed	`NCT03313674` - Investigation of Seasonal Variations of Brain Structure and Connectivity in SAD	N/A
Recruiting	`NCT05776602` - Fast Brain MRI in Children With Suspected Brain Tumor
Completed	`NCT05262790` - The Difference of Grey Matter Volume Among the Patients of Schizophrenia
Completed	`NCT03501004` - The Study of Acupuncture on Vascular and Functional Neuroimaging in Parkinson's Disease Patients With Sleep Disorders	N/A
Recruiting	`NCT05698511` - Neural and Physiological Correlates of Psychedelic Sub-states	Phase 1
Not yet recruiting	`NCT03591315` - Clinical Study of Structural and Functional Evaluation of the Visual Pathway
Recruiting	`NCT04951700` - Aging and Disease Course: Contributions to Lifespan Neurobiology of Schizophrenia
Not yet recruiting	`NCT05140850` - Long-term Consequences of Neuroimaging and Perceived Cognitive Dysfunction in oPRES
Completed	`NCT01514630` - Creatine as a Treatment Option for Depression in Methamphetamine Using Females	Phase 4
Completed	`NCT02939885` - fMRI Study of Brain Mechanisms Related to Emotions	N/A
Recruiting	`NCT04696315` - Early Diagnosis of SCD Based on Radiogenomics
Enrolling by invitation	`NCT01981148` - Measurement of Retinal Auto Fluorescence With a Fluorescence Lifetime Imaging Ophthalmoscope
Completed	`NCT03475823` - Cognitive and Blood Flow Effects of Mountain Tea	N/A
Completed	`NCT04135105` - Lexical Tone Perception in Tone language--a fMRI Study