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Clinical Trial Summary

This is a Phase 2 evaluation of hepatic-progression free survival among patients with Grade 2 liver-dominant NET metastases undergoing combination therapy with CapTem and Y90 radioembolization.The hypothesis is to confirm safety and to assess if disease control is improved relative to expectation from either therapy alone.


Clinical Trial Description

Patients with liver-dominant Grade 2 NET metastases from any primary will start CapTem and undergo simulation angiography for radioembolization planning during the first cycle. If they tolerate CapTem and are not excluded from radioembolization, then TARE will be performed on Day 7 of Cycle 2, with additional TARE of Day 7 of cycle 3 or 4 as needed to treat the entire tumor burden. Patients will remain on CapTem until progression or intolerance. Primary outcome measure is hepatic progression-free survival. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04339036
Study type Interventional
Source Abramson Cancer Center at Penn Medicine
Contact Michael Soulen, MD
Phone 855-216-0098
Email michael.soulen@pennmedicine.upenn.edu
Status Recruiting
Phase Phase 2
Start date October 7, 2021
Completion date May 1, 2026

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