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Clinical Trial Summary

The I-MAT trial is a randomised, placebo-controlled, phase II trial of adjuvant Avelumab in patients with stage I-III Merkel cell carcinoma aiming to explore the efficacy of avelumab as adjuvant immunotherapy.


Clinical Trial Description

The I-MAT trial is a phase II, prospective, randomised, placebo-controlled, multi-institutional trial for patients with stage I-III Merkel cell carcinoma (MCC). Participants on the trial will receive either avelumab or placebo for 6 months. The primary aim of the I-MAT trial is to develop an effective, well-tolerated adjuvant immunotherapy regimen for patients with stage I-III MCC, post a range of definitive loco-regional treatment options. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04291885
Study type Interventional
Source Melanoma and Skin Cancer Trials Limited
Contact Melanoma and Skin Cancer Trials Ltd Project officer
Phone +61 3 9903 9022
Email imat@masc.org.au
Status Recruiting
Phase Phase 2
Start date October 26, 2020
Completion date April 1, 2028

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