Clinical Trials Logo

Clinical Trial Summary

This observational study will investigate whether differences in birth events and oxygen levels during the newborn period affects the brain activity of children during the middle childhood years.


Clinical Trial Description

The investigators will conduct an observational study comparing two groups of children to determine whether differences in birth events and oxygen levels during the newborn period lead to structural and functional impairment within the brain's dopaminergic pathways and the cortical regions innervated by those pathways. The dopaminergic system is involved in modulating motor control and cognitive function. Using magnetic resonance diffusion tensor imaging, structural integrity of dopaminergic circuits will be quantified and compared in post-hypoxic former preterm children versus healthy control children born at term closely matched by age/sex/race. Functional activity during executive function tasks will be quantified and compared in post-hypoxic former preterm children versus healthy control children born at term using functional magnetic resonance imaging-blood oxygen level dependent (fMRI-BOLD). Assessment of motor function (grooved pegboard task) will also be performed. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03407729
Study type Observational
Source Case Western Reserve University
Contact
Status Completed
Phase
Start date June 8, 2018
Completion date February 17, 2020

See also
  Status Clinical Trial Phase
Recruiting NCT03222375 - SQUEDâ„¢ Series 28.1 Home-use and Treatment of Autowave Reverberator of Autism N/A
Completed NCT00247585 - Hangover, Congeners, Sleep and Occupational Performance Phase 2
Not yet recruiting NCT06396689 - NapBiome: Targeting Gut Microbiota and Sleep Rhythm to Improve Developmental and Behavioral Outcomes in Early Childhood N/A
Completed NCT02557425 - Prophylaxis Against Malaria to Enhance Child Development (PROTECT Study)
Completed NCT00515294 - Acute and Residual Effects of Caffeinated Beer Phase 2
Completed NCT03268590 - Neuroimaging During Pure Oxygen Breathing Phase 4
Recruiting NCT03862950 - A Trial of Metformin in Individuals With Fragile X Syndrome (Met) Phase 2
Active, not recruiting NCT04937452 - Dopaminergic Therapy for Frontotemporal Dementia Patients Phase 2
Terminated NCT01506349 - Assessing Neurocognitive Effects of Gluten Exposure N/A
Enrolling by invitation NCT05934422 - NiPPeR Randomised Trial - Child Follow Up Study N/A
Completed NCT01782378 - Scalp Application of LED Therapy to Improve Thinking and Memory in Veterans With Gulf War Illness N/A
Completed NCT01953068 - Executive Reaction Time Test in Assessment of Cognitive Dysfunction After Aortic Valve Procedures
Completed NCT01061242 - Intensive Care Unit (ICU) Sleep Quality and Neurocognitive Performance N/A
Terminated NCT02306460 - Frontal Cognitive Control Functions Before and After Percutaneous Catheter Procedures in Treatment of Atrial Fibrillation
Completed NCT02680210 - Self-defining Memories in Patients With a TBI N/A
Completed NCT00183170 - Residual Effects of Intoxication on Student Performance Phase 2
Completed NCT00586638 - Training Cognitive Control Processes in Older Adults N/A
Recruiting NCT05657860 - Guanfacine Extended Release for the Reduction of Aggression and Self-injurious Behavior Associated With Prader-Willi Syndrome Phase 4
Recruiting NCT04289142 - Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients Phase 4
Completed NCT01150071 - Growth, Health and Development in Children Born Extremely Preterm N/A