The Use of Exosomes In Craniofacial Neuralgia

Status Suspended

Clinical Trial Summary

This study is designed to evaluate the safety and efficacy of exosome deployment in patients with Craniofacial Neuralgia. Secondarily, this study is designed to rigorously evaluate for any adverse events that may be related to the administration and reception of exosomes.

Clinical Trial Description

The present study is designed to amplify the delivery of growth factors and anti-inflammatory agents to localized targets (determined by specific condition) by using focused transcranial ultrasound prior to intravenous infusion of exosomes. Exosomes delivered intravenously can be demonstrated to cross the blood brain barrier naturally. Exosomes are thought to play a normal physiological role in intercellular signaling, and demonstrate anti-inflammatory and pro-growth effects in preclinical models and clinical cases reports. Clinical trials have deployed exosomes intravenously and with intracerebral and intrathecal injection, and have claimed safety and clinical efficacy. Focused ultrasound has been shown to enhance local blood flow and has been presented as a non-invasive means of targeting delivery of therapeutic agents. ;

Study Design

Related Conditions & MeSH terms

Neuralgia

Clinical Trial Details

NCT number	NCT04202783
Study type	Interventional
Source	Neurological Associates of West Los Angeles
Contact
Status	Suspended
Phase	N/A
Start date	December 1, 2023
Completion date	December 1, 2024

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT04066933` - Forms of Cervical Brachial Syndrome Treated With Plasma Concentrate Enriched for A2M
Completed	`NCT01202227` - An Open-Label Long-Term Study Of Pregabalin For The Treatment Of Central Neuropathic Pain	Phase 3
Terminated	`NCT00964990` - A Study to Evaluate the Efficacy, Safety, and Tolerability of JNJ-42160443 in Patients With Neuropathic Pain (Postherpetic Neuralgia and Post-traumatic Neuralgia)	Phase 2
Completed	`NCT00922987` - Clinical Study With Lyrica In Patients Suffering From Epilepsy
Recruiting	`NCT00740571` - Amitriptyline or Pregabalin to Treat Neuropathic Pain in Incurable Cancer	Phase 3
Terminated	`NCT02747758` - Transcranial Direct Current Stimulation (tDCS) in Chronic Neuropathy	N/A
Completed	`NCT05464199` - Home-based EEG Neurofeedback for Chronic Neuropathic Pain	Phase 1
Completed	`NCT02490436` - Novel Treatment Option for Neuropathic Pain	Phase 2
Completed	`NCT01974791` - GET Living: Graded Exposure Treatment for Children and Adolescents With Chronic Pain	N/A
Completed	`NCT01279018` - Persistent Pain After Breast Cancer Treatment With Docetaxel	N/A
Not yet recruiting	`NCT00944502` - To Evaluate the Efficacy and Tolerability of the Use of Vitatonus Dexa Compared to Dexamethasone in Patients With Neuralgia of Various Origins	Phase 3
Completed	`NCT02957851` - EMONO for the Treatment of Peripheral Neuropathic Pain	Phase 2
Completed	`NCT02180880` - Symptom Based Treatment of Neuropathic Pain	Phase 4
Active, not recruiting	`NCT01508676` - Effects of Pennsaid on Clinical Neuropathic Pain	N/A
Completed	`NCT00631943` - A Study to Evaluate the Efficacy and Safety of Pregabalin (Lyrica) for the Treatment of Nerve Pain	Phase 3
Completed	`NCT03973983` - Comparison of Ultrasound-guided Transgluteal and Finger-guided Transvaginal Pudendal Nerve Block Techniques	N/A
Terminated	`NCT03296111` - Patients With Ocular Neuropathic Pain: Description of Pain and Impact on Their Quality of Life
Not yet recruiting	`NCT06398847` - Virtual Reality (VR) Self-Hypnosis Software	N/A
Terminated	`NCT02460107` - Botulinum Toxin Type A for Neuropathic Pain in Patients With Diabetic Peripheral Polyneuropathy	Early Phase 1
Recruiting	`NCT01788410` - MRI-Guided Cryoablation to Alleviate Pain in Head, Neck and Spine