Neuralgia, Postherpetic Clinical Trial
Official title:
Effect of Opioids in Neuropathic Pain in Postherpetic Patients
Postherpetic neuralgia (PHN) is often associated with pain and sensory changes and is the
leading type of neuropathic pain in modern clinical pain research. It is characterized by a
variety of sensory patterns, which may be categorized into "irritable nociceptor" and
"impairment of nociceptor". At date, several lines of evidence lead to the assumption, that
mechanical hyperalgesia in PHN is based - at least in part - on central nervous processes of
sensitization.
In animal studies the investigators have discovered a previously unrecognized effect of
opioids, the reversal of long-term potentiation (LTP) at C-fibre synapses, i.e. an
opioid-induced depotentiation. In principle, synaptic depotentiation may be permanent or
transient. In our study the clinically used ultra-short acting MOR agonist remifentanil
normalized synaptic strength after wash-out of the drug. At present it is not known whether
opioid-induced depotentiation can be used to the benefit of pain patients.
The aim is to study the hypothesis, that pain in a group of PHN patients with predominant
mechanical hyperalgesia is reversed by intravenous remifentanil at a plasma target
concentration of 18ng/ml (corresponding to about 0.75 µg/kg/min) for 60 minutes compared
with PHN patients of other sensory types.
n/a
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02484170 -
Mannitol Cream for Post Herpetic Neuralgia
|
Phase 1/Phase 2 | |
| Terminated |
NCT00964990 -
A Study to Evaluate the Efficacy, Safety, and Tolerability of JNJ-42160443 in Patients With Neuropathic Pain (Postherpetic Neuralgia and Post-traumatic Neuralgia)
|
Phase 2 | |
| Completed |
NCT00394901 -
A 13-Week, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study Of Pregabalin For Postherpetic Neuralgia
|
Phase 3 | |
| Completed |
NCT01252160 -
Safety and Effectiveness of Repeated Administration of QUTENZA Patches for Treatment of Pain Caused by Nerve Damage
|
Phase 4 | |
| Completed |
NCT00377598 -
Efficacy, Safety and Tolerability Study of TAK-583 in Subjects With Postherpetic Neuralgia
|
Phase 2/Phase 3 | |
| Completed |
NCT00160667 -
A Study Assessing Efficacy of Brivaracetam in Subjects With Persistent Pain After Shingles (Post-herpetic Neuralgia)
|
Phase 2 | |
| Terminated |
NCT00245544 -
Safety and Preliminary Efficacy of MK0759 in Postherpetic Neuralgia (PHN)(0759-004)
|
Phase 2 | |
| Completed |
NCT00335933 -
Safety and Efficacy of Gabapentin in Postherpetic Neuralgia
|
Phase 3 | |
| Completed |
NCT00617461 -
A Clinical Study in Subjects With Neuropathic Pain From PHN Who Have Had an Inadequate Response to Gabapentin Treatment
|
Phase 2 | |
| Withdrawn |
NCT02426411 -
Dose Ranging Trial to Determine the Safety and Efficacy of EMA401 in Patients With PHN
|
Phase 2 | |
| Completed |
NCT01129531 -
A Study of the Safety and Efficacy of AGN-214868 in Patients With Postherpetic Neuralgia
|
Phase 2 | |
| Completed |
NCT00674687 -
A Study Of The Efficacy Of Gabapentin In Neuropathic Pain Patients As Measured By Quantitative Sensory Testing
|
N/A | |
| Terminated |
NCT01678924 -
A Safety and Efficacy Study of AGN-214868 in Patients With Postherpetic Neuralgia
|
Phase 2 | |
| Completed |
NCT00424372 -
A Long-Term Study To Evaluate Safety And Efficacy Of Pregabalin For Postherpetic Neuralgia
|
Phase 3 | |
| Completed |
NCT00619476 -
A Study In Patients With Neuropathic Pain From Post-Herpetic Neuralgia (PHN)
|
Phase 2 | |
| Terminated |
NCT00295776 -
Lamictal in the Treatment of Post-Herpetic Neuralgia
|
Phase 2/Phase 3 | |
| Completed |
NCT00570310 -
Neuropathic Pain Syndrome Patient Study (MK-0000-072)
|
Phase 1 | |
| Terminated |
NCT00282763 -
A Research Study to Evaluate the Safety and Effectiveness of MK0686 for the Treatment of Postherpetic Neuralgia (Also Known as PHN or Post Shingles Pain) (0686-005)
|
Phase 2 | |
| Completed |
NCT00568321 -
RN624 For Pain Of Post-Herpetic Neuralgia
|
Phase 2 | |
| Completed |
NCT00614705 -
PH-797804 Versus Placebo For The Treatment Of Neuropathic Pain Associated With Post-Herpetic Neuralgia
|
Phase 2 |