Sex-Differential Health Interventions In Low-Birth-Weight Infants

Status Completed

Clinical Trial Summary

Our group has consistently found that the major interventions to reduce morbidity and mortality in low-income countries have sex-differential effects. These interventions include BCG vaccine, oral polio vaccination (OPV), and vitamin A supplementation (VAS). Low-birth-weight (LBW) children constitute the largest high-risk group in low-income countries. According to current policy, they receive OPV at birth. Current evidence suggests that a policy of providing BCG with OPV for girls and VAS instead of OPV for boys at birth may improve survival in LBW neonates. This will be tested in a large randomized trial. We experienced an unexpected cluster of deaths among boys in the VAS arm, which could be due to chance, but we decided to stop randomizing boys to OPV or VAS. Very recent evidence has suggested that low-birth-weight boys may benefit from BCG at birth as well. Hence, we have obtained ethical permission to continue the trial with randomization of boys to OPV or OPV plus BCG.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00625482
Study type	Interventional
Source	Bandim Health Project
Contact
Status	Completed
Phase	N/A
Start date	February 2008

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04507867` - Effect of a NSS to Reduce Complications in Patients With Covid-19 and Comorbidities in Stage III	N/A
Completed	`NCT04092465` - Outcomes of Surgical Resection After Induction Treatment in Non-Small Cell Lung Cancer (SRaIT)
Completed	`NCT03296423` - Bacillus Calmette-guérin Vaccination to Prevent Infections of the Elderly	Phase 4
Not yet recruiting	`NCT04900610` - The Effect of Vitamin K2 Supplementation on Arterial Stifness and Cardiovascular Events in PEritonial DIAlysis	N/A
Completed	`NCT04149873` - Effectness of Treatment With Mechanical Insufflation-Exsufflation	N/A
Completed	`NCT05905042` - Follow-up of Recovery Condition in Survivors of Acute Respiratory Distress Syndrome
Completed	`NCT00527774` - Effect of HCV Infection on Insulin Resistance and Malnutrition-inflammation Complex Syndrome in Regular Hemodialysis Patients	N/A
Completed	`NCT00518856` - Lufwanyama Neonatal Survival Project	N/A
Completed	`NCT06408636` - Prognostic Role of LA Strain in Acute Myocardial Infarction
Completed	`NCT06051526` - The African Critical Illness Outcomes Study
Recruiting	`NCT05055089` - Short- and Medium-term Results of New Generation Aortic
Active, not recruiting	`NCT04132492` - AGNES - Aging Nephropathy Study, a Prospective Observational Cohort of Chronic Kidney Disease in Elderly Patients
Completed	`NCT03885206` - Effectiveness and Clinical Outcomes of Municipal Acute Wards Versus a General Hospital	N/A
Completed	`NCT05573659` - Capillary Refill Time Calculated With a Video-assisted Method Has a Better Reproducibility Than Visual Method in Critically Ill Patients	N/A
Withdrawn	`NCT03245658` - The Effect of Cannabis in Pancreatic Cancer	Phase 2
Recruiting	`NCT04094428` - Burden, Mortality and Supply Costs in Intensive Care Unit Patients
Completed	`NCT01631799` - Outcome of Patients After Total Knee Replacement: A Comparison of Femoral Nerve Block and Epidural Anesthesia	N/A
Completed	`NCT00244673` - Randomized Study of Not Giving Diphteria-tetanus-pertussis Vaccination With or After Measles Vaccination	Phase 4
Completed	`NCT03378843` - Spermidine Intake and All-cause Mortality	N/A
Recruiting	`NCT04424511` - Effects of Mass Drug Administration of Azithromycin on Mortality and Other Outcomes Among 1-11 Month Old Infants in Mali	Phase 3