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Clinical Trial Summary

Evaluate the efficacy and safety of neoadjuvant chemotherapy (NAC) with albumin-bound paclitaxel and carboplatin followed by chemoradiation therapy (CRT) for stage IIIC cervical cancer patients with carcinoma >4 cm in greatest dimension and/or lymph node >2cm in short axis.


Clinical Trial Description

in this phase III tiral , stage IIIC cervical cancer patients with carcinoma >4 cm in greatest dimension and/or lymph node >2cm in short axis will be randomly assigned to two circles of NAC with albumin-bound paclitaxel and carboplatin followed by standard CRT with weekly cisplatin plus pelvic radiotherapy or to standard CRT alone. The primary end point was 3-year progression-free survival (PFS). Secondary end points were response rate, 3-year locoregional control, 3-year overall survival (OS), safety, and quality of life. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05367206
Study type Interventional
Source Sun Yat-sen University
Contact Junyun Li, M.D.
Phone 020-87343817
Email LIJUNY@sysucc.org.cn
Status Recruiting
Phase Phase 3
Start date March 14, 2022
Completion date March 31, 2027

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