Alteration of Stool Microbiota in Preterm Infants With Anemia

Status Active, not recruiting

Clinical Trial Summary

This study evaluates the relationship between anemia and stool microbiota in premature infants. It also evaluates the relationship between blood transfusion and stool microbiota.

Clinical Trial Description

Necrotizing enterocolitis (NEC) is a leading cause of death in preterm infants, yet the disease mechanism is not well understood. Among the factors that have been studied are the change in stool microbiota (dysbiosis), severe anemia, and transfusion. Studies suggest that dysbiosis occurs in neonates with NEC. Large studies and meta-analyses have shown a predominance of Gammaproteobacteria, a decrease in Firmicutes, and decreased bacterial diversity in stool from infants with NEC. Studies do not support a relationship between transfusions and NEC since there are conflicting findings on this topic. There is a suggestion, however, that severe anemia may be associated with NEC though this requires further study. No studies have been done evaluating the relationship between anemia and change in stool microbiota, or blood transfusion and change in stool microbiota. This study aims to primarily evaluate the relationship between anemia and stool microbiota, and secondarily evaluate the relationship between transfusion and stool microbiota. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03554278
Study type	Observational
Source	University of Texas Southwestern Medical Center
Contact
Status	Active, not recruiting
Phase
Start date	October 9, 2018
Completion date	October 31, 2024

View Details

See also
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