Clinical Trials Logo

Clinical Trial Details — Status: Not yet recruiting

Administrative data

NCT number NCT05289843
Other study ID # ENDO 3-7-2
Secondary ID
Status Not yet recruiting
Phase N/A
First received
Last updated
Start date May 2022
Est. completion date July 2023

Study information

Verified date March 2022
Source Cairo University
Contact Ayah Ta El Sayed, M.D.S
Phone 01221902479
Email ayahtarek94@gmail.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

To measure the Effect of Rosmarinus Officinalis versus 2.5%Sodium Hypochlorite as Root canal Irrigants on the Intensity of post-operative pain and Bacterial Reduction in asymptomatic necrotic Mandibular premolars.


Recruitment information / eligibility

Status Not yet recruiting
Enrollment 26
Est. completion date July 2023
Est. primary completion date July 2023
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 20 Years to 45 Years
Eligibility Inclusion Criteria: 1. Systematically healthy patient (ASA I and II). 2. Age between 20 and 45 years with no sex predilection 3. Mandibular permanent premolar teeth: - Diagnosed clinically with pulp necrosis. - Absence of spontaneous pain. - Radiographic evidence of root and root canal. - Slight widening in the periodontal membrane space or with periapical radiolucency. - No response to cold pulp tester (ethyl chloride spray) 4. Patients who can understand and interpret Numerical rating scale (NRS). 5. Patients' acceptance to participate in the trial Exclusion Criteria: - 1- Medically compromised patients having significant systemic disorders. (ASA III or IV). 2- History of intolerance to NSAIDS. 3- If analgesics or antibiotics have been administrated by the patient during the past 24 hours preoperatively as it might alter their pain perception. 4- Pregnant women: Avoid radiation exposure, anesthesia, and medication. 5- Teeth with: i. Vital teeth. ii. Double canal mandibular premolar teeth iii. Association with swelling or fistulous tract. iv. Acute peri-apical abscess and swelling: Need special treatment steps which could involve additional visits with incision and drainage. Also, it could influence initiation and progression of postoperative pain. v. Mobility Grade II or III. vi. Pocket depth more than 5mm. vii. Previous root canal therapy. viii. Non-restorable teeth: Hopeless tooth - Immature teeth. - Radiographic evidence of external or internal root resorption vertical root fracture, perforation, calcification.

Study Design


Related Conditions & MeSH terms


Intervention

Other:
Rosmarinus Officinallis
Root canal Irrigants

Locations

Country Name City State
n/a

Sponsors (1)

Lead Sponsor Collaborator
Cairo University

Outcome

Type Measure Description Time frame Safety issue
Primary Postoperative pain after root canal treatment. The patient is asked to grade his degree of pain on the Numerical Rating Scale (NRS) chart which is an 11 points scale consisting of numbers from 0 to 10, where zero reading represents no pain , 1-3 readings represent mild pain, 4-6 readings represent moderate pain. 7-10 readings represent severe pain . Up to 48 hours postoperative.
Secondary Intracanal bacterial load change. The intracanal bacterial load change is calculated through using colony forming units per milliliter test before and after root canal preparation. First as a base line and after 15 minutes ( End of the chemo-mechanical preparation).
See also
  Status Clinical Trial Phase
Not yet recruiting NCT04035330 - Effect of Etidronate in Sodium Hypochlorite Versus Sodium Hypochlorite on the Intensity of Postoperative Pain N/A
Completed NCT06418386 - Bacterial Reduction of Rotary Versus Manual Filing System Using Different Irrigants in Primary Molars N/A
Not yet recruiting NCT05522270 - Concentrated Growth Factor Versus Platelet Rich Fibrin in Revitalization of Necrotic Young Permanent Incisors N/A
Completed NCT04606719 - Healing Potentiality Of Blood Clot S-PRF and A-PRF in the Treatment Of Necrotic Mature Single-Rooted Teeth With Chronic Peri-Apical Periodontitis N/A
Not yet recruiting NCT05988788 - Effect of Epigallocatechin-3-Gallate Solution as a Root Canal Irrigant on Post-Operative Pain Intensity and Bacterial Load Reduction in Necrotic Tooth N/A
Completed NCT04983524 - Propolis Versus Calcium Hydroxide on Post-Operative Pain in Patients With Necrotic Pulp N/A
Not yet recruiting NCT06116214 - Effect of Vachellia Nilotica Versus Sodium Hypochlorite as Root Canal Irrigant on Postoperative Pain and Bacterial Load Reduction in Mandibular Premolar Teeth With Necrotic Pulp Phase 4
Not yet recruiting NCT03698188 - Comparative Evaluation of the Regenerative Capacity of Two Platelet Concentrates N/A
Not yet recruiting NCT06310044 - Effect of Commiphora Myrrh Solution as a Root Canal Irrigant on Post Operative Pain and Bacterial Load Reduction in Necrotic Tooth N/A
Completed NCT03084601 - Evaluation of Postoperative Pain After Using 3MIX-TATIN Versus Calcium Hydroxide Iodoform Paste In Necrotic Primary Molars Treated by Lesion Sterilization and Tissue Repair Therapy Phase 4
Not yet recruiting NCT03059290 - Incidence of Post-Operative Pain After Single Visit Root Canal Treatment in Necrotic Teeth Using Two Different Rotary Systems (Protaper Nex t& Neolix File) N/A
Completed NCT04646538 - Volume Assessment of the Periapical Healing Following Regenerative Endodontic Procedures Using Cone- Bean Computed Tomography Early Phase 1
Completed NCT03708081 - Comparative Evaluation of Different File Systems in Postoperative Pain
Not yet recruiting NCT05419752 - Clinical Assessment of 3 Differant Obturation Sealers on Postoprative Pain and Swelling Phase 2/Phase 3
Completed NCT05775081 - Treated Dentine Matrix and Platelet Rich Fibrin in Induction of Root Formation of Non-Vital Immature Permanent Teeth N/A
Not yet recruiting NCT03009006 - Post Operative Pain and Level of Endotoxins With Calcium Hydroxide and Calcium Hydroxide Mixed With Chlorhexidine in Treating Necrotic Teeth N/A
Not yet recruiting NCT05620147 - Effect of Apical Enlargement to Different Preparation Sizes and Tapers on Pain and Bacterial Reduction in Necrotic Pulp N/A
Not yet recruiting NCT05146713 - Effect of Propolis Nanoparticles on Postoperative Pain and Bacterial Reduction in Mandibular Premolars Phase 2/Phase 3
Not yet recruiting NCT04035070 - Effect of Irrigation With Antibiotic-containing Solutions on Postoperative Pain and Intra-canal Bacteria Phase 4
Not yet recruiting NCT04728386 - Postoperative Pain and Antibacterial Efficacy After Root Canal Irrigation With Curcumin or Sodium Hypochlorite N/A