Clinical Trials Logo

Clinical Trial Summary

This is a randomized double blinded trial to determine if a small dose of dexmedetomidine can prevent and relieve nausea and shivering, two of the more common complaints after cesarean delivery.


Clinical Trial Description

This study is a randomized, placebo controlled, double blind evaluation of the use of a single dose of dexmedetomidine for the prevention of shivering and nausea after cesarean delivery. It is hypothesized that patients who receive dexmedetomidine (as compared to placebo) will have a reduced severity of postoperative shivering and nausea. Study subjects will be have a scheduled cesarean section. They will receive written, informed consent obtained before surgery. After enrollment, patients will receive spinal anesthesia consisting of 11.25mg bupivacaine, 25 mcg of fentanyl, and 250 mcg of morphine. All IV fluid will be warmed. After delivery of the neonate, delivery of the placenta, and assurance of adequate uterine tone, patients will be randomized in a 1:1 fashion to receive a blinded study syringe consisting of either placebo saline, or 10 mcg of dexmedetomidine. Study outcomes will be measured on an 11-point Likert scale assessing shivering, nausea, pain, pruritus, and sedation. Assessments will be performed on admission to the recovery room, and at 30 and 60 minutes. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03370562
Study type Interventional
Source Beth Israel Deaconess Medical Center
Contact
Status Completed
Phase N/A
Start date February 18, 2020
Completion date December 31, 2020

See also
  Status Clinical Trial Phase
Completed NCT01217190 - Crossover Study Comparing Ondansetron Orally Dissolving Film Strip (ODFS) With Zofran Orally Disintegrating Tablets Phase 1/Phase 2
Recruiting NCT06302673 - The Role Of Laserpuncture For Prevention Of Nausea And Vomiting Post Strabismus Surgery With General Anesthesia In Adult Patients N/A
Recruiting NCT04563494 - The Effects of IV vs Oral Dexamethasone on Postoperative Nausea, Vomiting, and Pain Phase 4
Completed NCT00108095 - A Study To Evaluate An NK-1 Antiemetic For The Prevention Of Post Operative Nausea And Vomiting Phase 2
Not yet recruiting NCT05426278 - The Effect Of Intraoperative Forced Air Warmer Use, On Postoperative Nausea And Vomiting N/A
Withdrawn NCT04954365 - Post Operative Nausea and Vomiting (PONV) Rescue Outcomes After Amisulpride Treatment
Not yet recruiting NCT06356623 - A Risk Prediction Model of Postoperative Nausea and Vomiting in Patients With Liver Cancer
Withdrawn NCT05016076 - Multi-Strategy Intervention for Anesthesia Care of Obese Patients A Factorial Randomized Controlled Trial N/A
Not yet recruiting NCT04899817 - Granisteron Versus Metoclopramide in Laparoscopic Cholecystectomy Phase 4
Recruiting NCT05875077 - Propofol Versus Dexmedetomidine on the Incidence of Postoperative Nausea and Vomiting N/A
Completed NCT03338400 - Dexamethasone Administration To Improve Patient Recovery In Ambulatory Vaginal Prolapse Surgery: Is There A Role? Phase 2
Completed NCT05692245 - Dexamethasone vs Ondansetron After Cesarean Delivery Phase 4
Completed NCT03125941 - High vs Low Dose Dexamethasone on Complications in the Immediate Postoperative Phase After Mastectomy Phase 4
Completed NCT00326248 - Casopitant (Oral) And ZOFRAN To Prevent Postoperative Nausea And Vomiting In Women Phase 3
Completed NCT00334152 - Casopitant And ZOFRAN To Prevent Post Operative Nausea And Vomiting In Women Phase 3
Recruiting NCT03586817 - PALONOSETRON X FOSAPREPITANT IN PONV Phase 4
Not yet recruiting NCT06357234 - Aprepitant Treatment to Prevent Postoperative Nausea and Vomiting in Children Undergoing Scoliosis Surgery Phase 2
Completed NCT03045133 - QUALITY OF RECOVERY AFTER INTRAOPERATIVE MORPHINE OR METHADONE Phase 4
Not yet recruiting NCT06410365 - Impact of Intrathecal vs Intravenous Dexmedetomidine Phase 4
Recruiting NCT05474001 - Comparison Between IT Fentanyl and IV Granisetron in Prevention of Vomiting in CS Under Spinal Anesthesia N/A