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Therapeutic Control of Aspirin-Exacerbated Respiratory Disease With Ifetroban

Nasal Polyps Clinical Trial

Official title:
Therapeutic Control of Aspirin-Exacerbated Respiratory Disease

Clinical Trial Summary

The overall aim of the study is to determine the efficacy of oral ifetroban, a novel antagonist of T prostanoid (TP) receptors, as a treatment for patients with aspirin-exacerbated respiratory disease (AERD).

Clinical Trial Description

The protocol involves a 4-week, double-blind, placebo-controlled parallel-design trial of oral ifetroban in patients with AERD. At the end of the 4-week treatment phase (ifetroban or placebo) each subject will undergo a graded oral aspirin desensitization procedure in order to initiate high-dose aspirin therapy, which is standard-of-care at our institution and is the only available therapy known to modify the course of AERD. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03326063
Study type Interventional
Source Brigham and Women's Hospital
Contact
Status Completed
Phase Phase 2
Start date April 26, 2018
Completion date April 15, 2023
View Details
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