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Myopia clinical trials

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NCT ID: NCT04173780 Active, not recruiting - Childhood Clinical Trials

Topical 0.01% Atropine for the Control of Fast Progressing Myopia

Myopie-STOP
Start date: February 12, 2020
Phase: Phase 2/Phase 3
Study type: Interventional

Myopia prevalence has dramatically increased worldwide in recent years in the general population and among children. Progressive myopia increases gradually with growth until the age of 20-25 years. At the same time, there is a remarkable increase in the prevalence of severe myopia (more than -6 diopters). Severe myopia is associated with many complications, which can lead to blindness. There is thus an increase in the number of myopic patients in general, and severe myopic patients in particular. The management of myopia and its complications is therefore a major public health issue. All the means likely to slow the evolution of myopia (thus to limit the prevalence of strong myopia) must be developed to limit the consequences. 0.01% Atropine seems to be a drug with a great interest to slow down the progression of myopia. The aim of the present study is to evaluate the efficacy at 1 year of 0.01% atropine (1 drop per day administered for 1 year) on the reduction of fast progressing myopia in children aged 4 to 12, compared to a control group (instillation of a placebo).

NCT ID: NCT04161326 Recruiting - Refractive Errors Clinical Trials

Environmental Health and Myopia Prevention and Control

Start date: January 1, 2016
Phase:
Study type: Observational

Myopia is one of the major causes of low visual acuity during childhood. It is generally more prevalent in urban areas than in rural areas. Current evidence does not address our understanding of the myopia incidence and development and associated risk geographic factors, such as green spaces. Therefore, our study aimed to evaluate the association between geographic factors and myopia base on a population-based large-scaled cohort design.

NCT ID: NCT04140877 Withdrawn - Myopia Clinical Trials

Choroidal Changes Post Short Term Exposure To Virtual Reality Devices

MIRABILE
Start date: July 2020
Phase: N/A
Study type: Interventional

This is a prospective, randomized, controlled, contralateral eye, clinical study. The objective of the study is to determine the impact of Virtual Reality (VR) usage on choroidal thickness when viewed through a test display compared to a control (standard) VR display. The hypothesis is that there will be less choroidal thinning in the eye viewing the test VR screen compared to the eye viewing the control VR screen.

NCT ID: NCT04135209 Completed - Myopia Clinical Trials

Optical Coherence Tomography Angiography in Myopic Patients

Start date: January 1, 2018
Phase:
Study type: Observational [Patient Registry]

The aim of this study is to investigate the macular microvascular network alterations in high myopic eyes using optical coherence tomography angiography.

NCT ID: NCT04126057 Completed - Juvenile Myopia Clinical Trials

Myopia Assessment of Two Manufacturing Processes

MAPLE
Start date: December 2, 2019
Phase: N/A
Study type: Interventional

Randomized, controlled, multisite, subject- and observer-masked, contralateral clinical trial of 6-month duration to compare two SightGlass Vision Diffusion Optics Technology (DOT) spectacle lens manufacturing processes in reducing the progression of juvenile myopia.

NCT ID: NCT04111757 Completed - Myopia Clinical Trials

A Study With Technolas® TENEO 317 Model 2 Excimer Laser to Treat Participants With Myopia or Myopic Astigmatism

Start date: July 25, 2019
Phase: N/A
Study type: Interventional

The primary objective of this study is to collect safety and effectiveness data for the Technolas Teneo 317 Model 2 excimer laser for LASIK correction in participants with myopia and myopic astigmatism.

NCT ID: NCT04110067 Recruiting - Myopia Clinical Trials

Clinical Results of Small Incision Lenticule Extraction (SMILE) for the Correction of High Myopia

Start date: January 2016
Phase:
Study type: Observational

Small Incision Lenticule Extraction (SMILE) was introduced in 2011 using the VISUMAX femtosecond laser (Carl Zeiss Meditec, Jena, Germany). It is designed for correction of myopia and myopic astigmatism. It involves the creation of a corneal tissue disk called lenticule and its extraction through a minimally invasive incision, utilizing only a femtosecond laser. This enables rapid visual recovery with very little discomfort to the patient. This observational case series monitors visual and refractive outcomes of myopic correction for more than -7.75 D. It is to - gather long-term results and refractive stability - detect rare complications or side-effects - evaluate the efficacy in a large number of patients

NCT ID: NCT04080128 Active, not recruiting - Myopia Clinical Trials

Examination of Myopia Progression and Soft Bifocal Contact Lens Myopia Control

BLINK2
Start date: September 9, 2019
Phase: N/A
Study type: Interventional

This project intends to provide important, previously unmet answers regarding biological associations with myopia (nearsightedness) progression in order to improve the ability to predict patients who are most likely to benefit from myopia control, as well as questions frequently posed by patients and practitioners about the side effects, mechanism, and discontinuation of soft bifocal contact lens myopia control. The first three aims examine the association between biological variables that can be measured non-invasively and myopia progression, and they will be conducted regardless of the outcome of the currently in progress BLINK Study. The last three specific aims will be conducted if soft bifocal contact lenses slowed myopia progression by 30% or more in the BLINK Study, and they can be investigated with very few additional measurements.

NCT ID: NCT04077086 Not yet recruiting - Refractive Errors Clinical Trials

Correcting Myopia Among Secondary School Children to Increase Academic High School Attendance Rates in Rural Communities

SWISH
Start date: September 1, 2022
Phase: N/A
Study type: Interventional

Chinese children are some of the most short-sighted in the world, but only one in five children in poor areas who needs glasses has them. Our team has already shown in other trials that giving children free glasses leads to better grades and that free glasses have a bigger impact on grades than factors like parents' education level and the amount of money a family has. The effect on grades from glasses is greater than from other health services in school, like giving vitamins. Only about one in three children in rural western China goes on to a regular, non-vocational high school. The investigators would like to show the Chinese government strong evidence of what glasses can do to help children continue their education, in order to help convince the government to carry out national programs to provide free glasses for children who need them. Study Plan: The investigators will choose 130 middle schools at random in Ningxia, western China, and all children in Years 1 and 2 (one class each) at each school will go at random into one of two groups: either a group getting free glasses, with support from teachers to push them to wear the glasses ("Intervention") or a group getting just glasses prescriptions ("Control.") The main study outcome will be the proportion of children going on to academic (as opposed to vocational) high school, and the study is powered to detect a 10% difference in this figure between groups.The study will also assess children's test scores, whether they wear their glasses at school, and how often they use blackboards (which disadvantage short-sighted children) vs textbooks to learn from. These other outcomes will help us to better understand the causal pathway between vision and high school attendance. We will also study the total cost of providing glasses glasses and the teacher support to wear them per additional student attending academic high school. The hypothesis of this study is that providing glasses will increase academic high school attendance.

NCT ID: NCT04073238 Active, not recruiting - Myopia Clinical Trials

Efficacy of Repeated Low-Level Red-Light Therapy in Myopia Control

Start date: July 23, 2019
Phase: N/A
Study type: Interventional

The purpose of this study is to determine if repeated low-level red-light therapy can slow myopia progression in Chinese schoolchildren.