Frequency and Risk Factors of Acute Myeloid Leukemia

Myeloid Leukemia Clinical Trial

Official title:

Frequency and Risk Factors of Acute Myeloid Leukemia at Clinical Haemtology Unit of Assiut University Hospital

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05787951
• Other study ID #: Risk factors of AML
• Status: Not yet recruiting
• Start date: May 1, 2023
• Est. completion date: August 1, 2025

Study information

• Verified date: March 2023
• Source: Assiut University
• Contact: Sanaa Hussien
• Phone: 00201023127310
• Email: Sanaaezzate212[@]gmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

1. to assess the frequency of acute myeloid leukemia at clinical Haematology unit of Assiute university hospital

2. to study correlations of known risk factors and if there are new risk factors participate in increasing frequency of acute myeloid leukemia

Description:

Acute myeloid leukaemia (AML) is a rare heterogeneous disease comprising a group of hematopoietic neoplasms originating from the excessive clonal proliferation of myeloid pre- cursor cells [1]. Diagnosis of AML is based on morphological diagnosis with proliferation of blast cells ≥ 20% of bone marrow cells, flow cytometric analysis and cytogenetic abnormalities, including the t(8;21)(q22;q22), t(15;17) (q22;q12) and inv (16)(p13.1;q22) which are associated with longer remission and survival, while alterations of chromosomes 5, 7, complex karyotype and 11q23 are associated with poor response to therapy and shorter overall survival [2] The etiological agent and pathogenesis of AML are not entirely clear, only few AML cases can be accurately classified through traditional cellular morphological classification [3]It is the most common acute leukaemia in adults. It accounts for 1.3% of new cancer patients in the United States, in 2018[ 4] Some factors are well documented to increase the risk of some types of leukemia such as benzene exposure and ionizing radiation [5] increased frequency of acute myeloid leukemia has been noticed at Haematology unit so the aim of the study to assess the the frequency of acute myeloid leukemia and to evaluate the risk factors for it .

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 200
• Est. completion date: August 1, 2025
• Est. primary completion date: May 1, 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• Adult Patients(above 18 years) diagnosed as acute myeloid leukemia according to WHO diagnostic criteria

Exclusion Criteria:

• Patients with other types of leukemia

Related Conditions & MeSH terms

• Leukemia
• Leukemia, Myeloid
• Leukemia, Myeloid, Acute
• Myeloid Leukemia

Intervention

Diagnostic Test:
• Bone marrow aspirite for diagnosis
Routine investigation of acute myeloid leukemia such as bone marrow aspirite for diagnosis ,cbc

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

References & Publications (1)

Hwang SM. Classification of acute myeloid leukemia. Blood Res. 2020 Jul 31;55(S1):S1-S4. doi: 10.5045/br.2020.S001. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Frequency of acute myeloid leukemia at clinical Haemtology unit of Assiute university hospital		Two years
Secondary	Risk factors of acute myeloid leukemia at clinical Haemtology unit of Assiute university hospital		Two years