Myelodysplastic Syndromes Clinical Trial
Official title:
Total Marrow and Lymphoid Irradiation and Chemotherapy Prior to Allogeneic Hematopoietic Cell Transplant for Myelodysplastic Syndrome or Acute Leukemia
RATIONALE: Giving chemotherapy and total marrow and lymphoid irradiation before allogeneic
hematopoietic cell transplant helps stop the growth of leukemia cells. It may also stop the
patient's immune system from rejecting the donor's stem cells. When the healthy stem cells
from a donor are infused into the patient they may achieve brand new hematopoietic recovery.
Sometimes the transplanted cells from a donor can make an immune response against the body's
normal cells, resulting in graft versus-host disease.
PURPOSE: This study is to evaluate the toxicity and efficacy of total marrow and lymphoid
irradiation conditioning when given together with combination chemotherapy and allogeneic
peripheral blood stem cell transplant in treating patients with myelodysplastic syndrome or
acute leukemia.
Patient receives preparative therapy including cyclophosphamide and total body irradiation (TBI) of 10 Gy or total marrow and lymphoid irradiation (TMLI) of 12-20 Gy, and starts immunosuppressive therapy using cyclosporine or tacrolimus, methotrexate-based prophylaxes, followed by peripheral blood stem cell transplantation and granulocyte colony-stimulating factor administration. ;
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