Muscle Weakness Clinical Trial
— MDmuscleXLHOfficial title:
Prospective Analysis of Quantitative and Qualitative Muscle Abnormalities in Children With X-linked Hypophosphatemia (XLH)
XLH rickets is a rare disease with muscle weakness. Fat parameters such as IMAT and intraMAT could be increased in this disease. IMAT and intraMAT will be calculated on MRI for 11 XLH children versus 20 typically developing children. The investigator will compare the percentage of IMAT in the XLH group versus control group and the difference concerning the intraMAT between the two groups.
Status | Not yet recruiting |
Enrollment | 30 |
Est. completion date | June 15, 2023 |
Est. primary completion date | June 15, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 5 Years to 17 Years |
Eligibility | Inclusion Criteria common criteria to the 2 groups: - Age: between 5 and 17 years. - Sex: male or female. - Informed consent, signed by both parents or holder of parental autority after being informated of the study. - Affiliation to a social security schema or having the right to. Inclusion criteria for XLH Patients : - Patient suffer of X-linked hypophosphatemia rickets. - Severity of clinical and radiological damage (pain, muscle weakness and severe bone deformities). - Growth in progress (bone age less than 15 years). - Child under conventional treatment: patient responding to conventional treatment or - under treatment with Burosumab (patient in treatment failure under treatment conventional). incluion criteria for helthy volunteers : - Healthy voluntary subjects, not suffering from XLH. - Matching by age (+/- 6 months) and sex. Exclusion Criteria common to the 2 groups : - Not being able to stay still during the MRI examination (approximately 45 min). - Growth completed. - History of lower limb surgery. - Contraindications to MRI - Holders of parental authority under AME. - Holders of parental authority under tutorship / curatorship. Exclusion criteria for Healthy volunteers : - Patients with endocrine, contracted or muscular pathology. - Patient receives a long-term treatment. - Patients with a high athletic level. - BMI-IOTF <20 or> 27.8 |
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
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Assistance Publique - Hôpitaux de Paris |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Quantify and compare muscle composition in XLH children versus healthy control children to demonstrate a link between muscle function and muscle quality. | calculation of inter-muscular adipose tissue will be done in cm2 | 1 day | |
Secondary | Measurement of muscle strength on force platforms, during gait analysis. Power test by mechanography of the jump (bipod and monopodal). Grasping test and correlation of fatty infiltration and functional data. | The Outcome Measure is BMI (Kg/m²) | 1 day | |
Secondary | Quantitative analysis of the muscles of the lower limbs (volume and length) | The Outcome Measure is BMI (Kg/m²) | 1 day |
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