General Anesthesia With and Without Muscle Relaxation and Muscle Strength Recovery

Muscle Weakness Clinical Trial

Official title:

Comparison of General Anesthesia With Use of Muscle Relaxation and General Anesthesia Without Muscle Relaxation on Recovery of Muscle Strength of the Patients

Clinical Trial Details — Status: Enrolling by invitation

Administrative data

• NCT number: NCT04760912
• Other study ID #: 022
• Status: Enrolling by invitation
• Phase: N/A
• Start date: April 1, 2020
• Est. completion date: September 2022

Study information

• Verified date: March 2022
• Source: Clinical Hospital Centre Zagreb
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Neuromuscular blocking agents are often used during general anesthesia. Also, general anesthesia may be performed without use of neuromuscular blocking agents.

Avoiding neuromuscular relaxation enables better muscle strength recovery.

Description:

Rocuronium is well used neuromuscular blocking agent during general anesthesia. Although very often used, neuromuscular blocking agents may sometimes have consequence in form of residual neuromuscular block.

Tha aim of the study is to compare influence of rocuronium during general anesthesia on muscle strength recovery measured by hand grip dynamometer. Measuremwnt of hand grip strength is perforrmed before and after general anesthesia. This research should contribute to better choice of anesthesia technique and better quality of patient recovery, as studies so far have not been detaily carried out.

Hypothesis of the research is that anesthesia without use of neuromuscular blocking agents may enable better recovery of muscle strength in immediate postoperative period.

Recruitment information / eligibility

• Status: Enrolling by invitation
• Enrollment: 60
• Est. completion date: September 2022
• Est. primary completion date: August 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• patients ASA status I-III for surgery under general anesthesia

• signed informed consent for participating in research

Exclusion Criteria:

• neuromuscular disease

• poorly controled chronic or acute cardiovascular, respiratory or autoimmune disease

• known allergic reaction to any medication used in this research

• pregnancy

• refusal to participate in this research

Related Conditions & MeSH terms

• General Anaesthesia
• Muscle Weakness
• Rocuronium

Intervention

Drug:
• Rocuronium
Rocuronium used for neuromuscular blokade during anesthesia and anesthesia without rocuronium

Procedure:
• General anesthesia for surgery
General anesthesia with standard anesthetic monitoring,

Locations

Country	Name	City	State
Croatia	UHCZagreb	Zagreb

Sponsors (1)

Lead Sponsor	Collaborator
Clinical Hospital Centre Zagreb

Country where clinical trial is conducted

Croatia, 

References & Publications (3)

Bowman WC. The neuromuscular junction: recent developments. Eur J Anaesthesiol. 1985 Mar;2(1):59-93. Review. — View Citation

Fuchs-Buder T, Schmartz D. [Residual neuromuscular blockade]. Anaesthesist. 2017 Jun;66(6):465-476. doi: 10.1007/s00101-017-0325-1. Review. German. Erratum in: Anaesthesist. 2017 Aug;66(8):578. — View Citation

Gätke MR, Viby-Mogensen J, Rosenstock C, Jensen FS, Skovgaard LT. Postoperative muscle paralysis after rocuronium: less residual block when acceleromyography is used. Acta Anaesthesiol Scand. 2002 Feb;46(2):207-13. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Muscle strenght recovery after general anesthesia	Change in muscle strength recovery measured with hand grip dynamometer after general anesthesia with or without rocuronium. Better understanding of mechanism how neuromuscular blockade influences quality if patient recovery due to muscle strength recovery	Perioperative