Muscle Weakness Clinical Trial
Official title:
The Effects of Resistance Training Intensity on Muscular Hypertrophy and Strength in Young, Resistance Trained Men
Verified date | March 2016 |
Source | McMaster University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
When practicing weightlifting regularly the body makes new proteins within the muscle.
These new proteins can increase the size of the cells within the muscle to make them larger,
a process called hypertrophy. The common convention surrounding gains in skeletal muscle size
and strength is that heavy weights are needed. In contrast, lifting lighter weights are
thought to be required to induce muscular endurance and not to promote growth. However, it
has previously been shown in untrained men that lifting lighter weights results in similar
gains in muscle mass and strength as lifting heavier weights. The purpose of this study is to
examine how performing resistance training of different intensities (light or heavy weights)
affects the degree of muscle growth and strength gain in individuals who are already
resistance training.
This information will be valuable when designing exercise protocols for increasing muscle
size and strength at all ages, or in individuals returning from injury, as a way to stimulate
muscle growth and promote strength gains without the need to lift heavy weights.
Status | Completed |
Enrollment | 50 |
Est. completion date | March 2016 |
Est. primary completion date | December 2015 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 30 Years |
Eligibility |
Inclusion Criteria: - Male - Aged 18-30 years old - Non-obese (Body mass index less than 30 kg/m2) - Non-smoker - Healthy based on questionnaire responses (see exclusion criteria) - Resistance trained (Resistance training > 2 times per week for 2 years, minimum 1 lower body exercise session per week) Exclusion Criteria: - Allergies to milk proteins (whey or casein) - Any acute or chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other metabolic disorders-all ascertained through medical history screening questionnaires - Arthritic conditions - Individuals who consume any analgesic or anti-inflammatory drug(s), prescription or non- prescription, chronically will be excluded - A history of neuromuscular problems - Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications). |
Country | Name | City | State |
---|---|---|---|
Canada | Exercise Metabolism Research Laboratory, McMaster Univeristy | Hamilton | Ontario |
Canada | McMaster University | Hamilton | Ontario |
Lead Sponsor | Collaborator |
---|---|
McMaster University |
Canada,
Morton RW, Oikawa SY, Wavell CG, Mazara N, McGlory C, Quadrilatero J, Baechler BL, Baker SK, Phillips SM. Neither load nor systemic hormones determine resistance training-mediated hypertrophy or strength gains in resistance-trained young men. J Appl Physi — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Muscle Volume | Change from baseline at 12 weeks Measured via 4 compartment model | 0 weeks (baseline) and 12 weeks | |
Secondary | Gene expression | Change from baseline at 12 weeks . Gene expression for proteins involved in muscle protein synthesis measured from muscle biopsy. | 0 weeks (baseline) and 12 weeks |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05543980 -
Leg Heat Therapy in Elderly Individuals
|
Phase 2 | |
Enrolling by invitation |
NCT03297632 -
Improving Muscle Strength, Mass and Physical Function in Older Adults
|
N/A | |
Completed |
NCT04207359 -
Effects of Creatine Supplementation in Breast Cancer Survivors
|
N/A | |
Completed |
NCT06216015 -
Exercise Training and Kidney Transplantation
|
N/A | |
Completed |
NCT04076982 -
Effect of Supplementary Dietary Protein (21g Per Day) on Lean Mass and Strength in Sedentary, Adult Vegetarians
|
N/A | |
Not yet recruiting |
NCT03662555 -
Effect of Neuromuscular Electrical Stimulation Combined With Blood Flow Restriction on Muscular and Cardiovascular Function
|
N/A | |
Completed |
NCT02530723 -
Functional Changes and Power Training in Older Women.
|
N/A | |
Completed |
NCT01743495 -
CAPABLE for Frail Dually Eligible Older Adults
|
N/A | |
Completed |
NCT01704976 -
SR-WBV Training for Frail Elderly in the Skilling up Stage
|
N/A | |
Completed |
NCT00183040 -
HORMA: Hormonal Regulators of Muscle and Metabolism in Aging
|
Phase 2 | |
Enrolling by invitation |
NCT06432062 -
Investigation the Effect of Rectus Abdominis and Erector Spinae Muscle Fatigue on the Viscoelastic Properties of Thoracolumbal Fascia
|
||
Recruiting |
NCT05073224 -
Muscle Function After Childbirth
|
N/A | |
Completed |
NCT04956705 -
Vitamin D and Calcium Supplementation at Danish Nursing Homes
|
N/A | |
Recruiting |
NCT03810768 -
Metabolomics Study on Postoperative Intensive Care Acquired Muscle Weakness
|
||
Completed |
NCT00060970 -
Evaluating Muscle Function After Ankle Surgery
|
N/A | |
Completed |
NCT04546048 -
The Early Strength Training Program in Post-transplant Liver Cases
|
N/A | |
Completed |
NCT03628365 -
Can Beta-Hydroxy-beta-Methylbutyrate Supplementation Counteract Muscle Catabolism in Critically Ill Patients?
|
N/A | |
Completed |
NCT05056298 -
Effect of Insole Added to Exercise in Patients With Bilateral Flexible Flatfoot
|
N/A | |
Completed |
NCT02739464 -
Effect of In-Patient Exercise Training on Length of Hospitalization in Burned Patients
|
N/A | |
Completed |
NCT05497960 -
Vivo Prediabetes Study: Online, Live, and Interactive Strength Training for Older Adults With Prediabetes
|
N/A |