Vegan or Animal Protein Ingestion on the Recovery of Muscle Function Following Exercise

Muscle Recovery Clinical Trial

— VAMPIRE  

Official title:

The Effect of Vegan or Animal Protein Ingestion on the Recovery of Skeletal Muscle Function Following Strenuous Exercise

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04156386
• Other study ID #: 190703-B-01
• Status: Completed
• Phase: N/A
• Start date: September 23, 2019
• Est. completion date: April 23, 2022

Study information

• Verified date: March 2023
• Source: University of Exeter
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study will assess the effect of daily post-exercise vegan (pea) and animal (whey) protein ingestion compared to placebo over 7 days of recovery from strenuous exercise. Muscle strength and soreness will be measured daily, and mechanisms underpinning recovery will be investigated in muscle biopsies taken 3, 24 and 48 hours after exercise.

Description:

Strenuous exercise can cause muscle soreness and reduced muscle strength. It is widely acknowledged that nutritional supplements derived from animal protein sources, including whey from milk, aids recovery when taken immediately after strenuous exercise. However, the effect of vegan protein supplements are less understood, and how they affect recovery of strength and soreness is not known. This is an important area of research due to the increasing demand for plant-based protein.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: April 23, 2022
• Est. primary completion date: April 23, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Recreationally active
• 18-40 years of age

Exclusion Criteria:

• Regular and structured involvement in resistance training
• Inactive participants
• Habitual dietary protein intake <0.8g/kg bw/day and >2.0g/kg bw/day
• Use of nutritional supplements
• Any diagnosed metabolic conditions (diabetes), cardiovascular disease or hypertension
• Current musculoskeletal injury
• Use of anti-inflammatory medicines
• Individuals with non -removable metallic implants (including heart pacemaker, cochlea implants, medication pumps, surgical clips, plates or screws) or claustrophobia
• Individuals with an allergy to egg, fish, wheat or soy ingredients as the product is manufactured in a facility that contains these ingredients

Related Conditions & MeSH terms

• Muscle Recovery

Intervention

Dietary Supplement:
• Recovery animal (20g whey) protein supplement
Animal protein supplement consumed post exercise to aid recovery of muscle function following strenuous exercise.
• Recover vegan (26g pea) protein supplement
Vegan protein supplement consumed post exercise to aid recovery of muscle function following strenuous exercise.
• Placebo (32g maltodextrin)
Placebo consumed post exercise to aid recovery of muscle function following strenuous exercise.

Locations

Country	Name	City	State
United Kingdom	University of Exeter	Exeter

Sponsors (2)

Lead Sponsor	Collaborator
University of Exeter	Beachbody

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in isokinetic work (W30) performed before and every 24 h after performing 300 maximal eccentric quadriceps contractions.	The recovery of skeletal muscle isokinetic force production following eccentric exercise using an isokinetic dynamometer	Once per 24 hour period for 7 days
Secondary	Perceived quadriceps muscle soreness	Soreness will be assessed using a visual analogue scale (VAS) to determine whether the protein supplement can reduce muscle soreness following eccentric exercise. This scale will represent a 100mm line with no pain and worst pain anchored at either end of the scale.	Once per 24 hour period for 7 days
Secondary	Muscle swelling	Determine whether the protein supplement can reduce muscle swelling following eccentric exercise assessed using MRI	Once per 24 hour period for 3 days
Secondary	Rate of protein incorporation into the muscle	Determine whether the strenuous exercise and a protein supplement can upregulate protein synthesis following strenuous exercise assessed by muscle biopsies	Once per 24 hour period for 3 days
Secondary	Plasma creatine kinase (CK) activity before and every 24 h after performing 300 maximal eccentric quadriceps contractions.	Damage and inflammatory bio markers following strenuous exercise assessed by blood sample	Once per 24 hour period for 7 days
Secondary	Change in flow mediated dilation	Determine whether the protein polyphenol supplement can impact vascular function following eccentric exercise	Once hourly post exercise for 3 hours