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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT04121689
Other study ID # 14234
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date October 1, 2014
Est. completion date August 26, 2019

Study information

Verified date August 2019
Source University of Illinois at Urbana-Champaign
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The anabolic action of 'fast' whey protein on the regulation of postprandial muscle protein synthesis has been established to be short-lived in healthy young adults. Our aim was assess the time course of anabolic signaling events and stimulation of muscle protein synthesis rates (MPS) after ingestion of a food source that represents a more typical meal-induced pattern of aminoacidemia, namely milk protein concentrate, in healthy young males.


Recruitment information / eligibility

Status Completed
Enrollment 7
Est. completion date August 26, 2019
Est. primary completion date November 1, 2014
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Male
Age group 18 Years to 35 Years
Eligibility Inclusion criteria

- Males

- Aged between 18-35 years

- Healthy, recreationally active

- BMI < 30 kg/m2

Exclusion criteria

- Smoking

- Allergies to milk proteins

- Vegetarians

- Diagnosed GI tract diseases

- Female

- Arthritic conditions

- A history of neuromuscular problems

- Previous participation in amino acid tracer studies

- Predisposition to hypertrophic scarring or keloid formation

- Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).

Study Design


Related Conditions & MeSH terms


Intervention

Dietary Supplement:
Milk Protein Concentrate
The macronutrient composition and energy of the milk protein beverage provided to participants is 38 g protein (3.46 g leucine), 4.17 g carbohydrate, and 1.4 g fat. The milk protein met all chemical and bacteriologic specifications for human consumption. The L-[1-13C]phenylalanine and L-[1-13C]leucine enrichments in the milk protein concentrate averaged 38.3 and 10.8 mole percent excess (MPE), respectively.

Locations

Country Name City State
United States Freer Hall Urbana Illinois

Sponsors (1)

Lead Sponsor Collaborator
University of Illinois at Urbana-Champaign

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Fractional synthesis rates of myofibrillar protein Myofibrillar protein synthesis rates will be assessed during the postabsorptive period for 3 hours, and every 1-2 hours during the 5 hours after protein ingestion. This will allow us assess the timecourse of muscle protein synthesis after eating. 8 hours
Secondary Phosphorylation of muscle anabolic signaling Phosphorylation of anabolic signaling pathways (mTORC1, AKT, and P70S6K) involved in the stimulation of myofibrillar protein synthesis rates will be assessed during the postabsorptive period for 3 hours, and every 1-2 hours during the 5 hours after protein ingestion. 8 hours
Secondary Exogenous rate of phenylalanine appearance Dietary derived phenylalanine availability will be measured during the 5 h postprandial phase to determine its relationship with the fractional synthesis rates of myofibrillar protein and phosphorylation of muscle anabolic signaling 5 hours
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