Clinical Trials Logo

Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT05876299
Other study ID # 23257
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date July 15, 2023
Est. completion date July 1, 2024

Study information

Verified date August 2023
Source University of Illinois at Urbana-Champaign
Contact Andrew T Askow, MS
Phone (608) 630-0237
Email askow2@illinois.edu
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The amount and quality of skeletal muscle mass determines physical performance, but also a significant contributor to metabolic health. As such, the maintenance of skeletal muscle mass is relevant across the lifespan to remain active in family and community life. Food ingestion, particularly protein, is one of the main anabolic to skeletal muscle tissue by stimulating muscle protein synthesis rates. There have been multiple attempts to identify specialized performance nutrition products (e.g., various isolated protein powders) to maximize the anabolic properties of dietary protein on muscle. Our research group, however, has advocated for a food focus approach to meet dietary protein requirements. Particularly, we propose that whole foods demonstrate food matrix effects (nutrient-nutrient interactions) that creates a greater anabolic action on muscle beyond what amino acids can create alone. Therefore, the objective of this study is to identify the anabolic properties of consuming lipid-rich pork products when compared to their leaner counter-parts. Our working hypothesis that the ingestion of 84% or 96% lean ground pork condition will stimulate a greater increase in muscle protein synthesis rates compared to an isocaloric carbohydrate beverage in healthy adults. We further hypothesize that the ingestion of 84% lean pork will augment the stimulation of muscle protein synthesis rates to a greater extent than 96% lean ground pork. To achieve our objective, we will recruit 15 healthy men and women (20-50 y) to receive prime-constant infusions to directly measure muscle protein synthesis rates before and after treatment ingestion using our lab's established methods.


Recruitment information / eligibility

Status Recruiting
Enrollment 15
Est. completion date July 1, 2024
Est. primary completion date March 1, 2024
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 20 Years to 50 Years
Eligibility Inclusion Criteria: - Age 20-50 yrs - Pre-menopausal - Recreationally active - Weight stable for prior 6 months Exclusion Criteria: - Age outside of range (20 - 50 yrs) - Pregnancy - Irregular menstrual cycles - Participation in previous research using [13C6]phenylalanine - Participation in other ongoing research that interferes with this study (e.g., conflicting diet, activity interventions, etc.) - Any hospitalization or surgery for a metabolic, cardiovascular, or neuromusculoskeletal complication within the past year - Allergy or hypersensitivity to local anesthetics, latex, or adhesives (bandages, medical tape, etc.) - Excess scarring after injury - History of excess bleeding after cut - Chronic or frequent dizziness/fainting, and arm or leg weakness/numbness - Arthritis - Tumors - Mental Illness - Hepatorenal, cardiovascular musculoskeletal, autoimmune, or neurological disease or disorder - Predisposition to hypertrophic scarring or keloid formation - Physical activity limitations - Consumption of ergogenic-levels of dietary supplements that may affect muscle mass (e.g., creatine, HMB), insulin-like substances, or anabolic/catabolic pro-hormones (e.g., DHEA) within 6 weeks prior to participation - Consumption of thyroid, androgenic, or other medications known to affect endocrine function - Consumption of medications known to affect protein metabolism (e.g., prescription-strength corticosteroids, non-steroidal anti-inflammatories, or acne medication) - Unwillingness to comply with study procedures - Weight unstable (variation >5% of bodyweight in last 6-12 months) - Current or previous tobacco use with last 6 months - Obesity (body mass index; BMI > 30 kg/m^2) - Score of less than 14 or greater than 24 on Godin-Shephard Leisure-Time Physical Activity Questionnaire - Phenylketonuria - Anyone hospitalized previously for COVID-19 without a cardiovascular workup screening for cardiovascular issues post-infection - Anyone recovering from COVID-19 infection within the preceding 10 days

Study Design


Related Conditions & MeSH terms


Intervention

Other:
95.1% Lean Pork
This intervention will contain 120 kcals, 4.4 g fat, and 20 g protein from low-fat ground pork.
81.16% Lean Pork
This intervention will contain 266 kcals, 20.6 g fat, and 20 g protein from high-fat ground pork.
Carbohydrate Beverage
This intervention will contain 266 kcals and 73.3 g carbohydrate from a carbohydrate beverage.

Locations

Country Name City State
United States Louise Freer Hall (University of Illinois Urbana-Champaign) Urbana Illinois

Sponsors (1)

Lead Sponsor Collaborator
University of Illinois at Urbana-Champaign

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Myofibrillar Fractional Synthetic Rate Rate of building new protein in skeletal muscle contractile protein During 5-hour post-prandial period following consumption of the study meal or beverage
Secondary Plasma Amino Acid Concentration Concentration of amino acids in plasma as determined by LC/MS/MS During the 3-hour post-absorptive period prior to ingestion of the study meal or beverage and throughout the 5-hour post-prandial period following meal ingestion
Secondary Plasma Free Fatty Acid Concentration Concentration of amino acids in plasma as determined by GC-MS During the 3-hour post-absorptive period prior to ingestion of the study meal or beverage and throughout the 5-hour post-prandial period following meal ingestion
Secondary Plasma Insulin Concentration Concentration of insulin in plasma as determined by commercially-available ELISA kits During the 3-hour post-absorptive period prior to ingestion of the study meal or beverage and throughout the 5-hour post-prandial period following meal ingestion
Secondary Plasma Glucose Concentration Concentration of glucose in plasma as determined by an automated biochemistry analyzer (YSI) During the 3-hour post-absorptive period prior to ingestion of the study meal or beverage and throughout the 5-hour post-prandial period following meal ingestion
See also
  Status Clinical Trial Phase
Completed NCT05386771 - Effects of Whey and Collagen Protein Blend on Protein Synthesis Rates N/A
Recruiting NCT05711095 - The Anabolic Properties of Fortified Plant-based Protein in Older People N/A
Withdrawn NCT00653679 - Exercise and Muscle Protein Signalling N/A
Completed NCT03372928 - Essential Amino Acids and Protein Kinetics During Caloric Deprivation N/A
Completed NCT04121689 - Time Course of Postprandial Protein Metabolism N/A
Completed NCT03303729 - Influence of Carbohydrate on Amino Acid Absorption From Dietary Protein (ICADP) N/A
Not yet recruiting NCT02732353 - Absorption and Muscle-stimulating Effect of Hydrolyzed and Minced Beef N/A
Completed NCT04302038 - The Effects Potato Protein on Rates of Myofibrillar Muscle Protein Synthesis in Young Women N/A
Completed NCT03994198 - Effect of Protein Quality During Overreaching in Trained Cyclists N/A
Active, not recruiting NCT05347667 - Menstrual Cycle Phase Muscle Protein Synthesis N/A
Completed NCT04894747 - Mycoprotein and Pea Protein Blend and Muscle Protein Synthetic Response N/A
Recruiting NCT05664269 - Anabolic Properties of Canola N/A
Completed NCT05353595 - The Effect of Mealworm Protein Ingestion on Muscle Protein Synthesis After Running Exercise in Humans N/A
Completed NCT05151887 - The Impact of a Whole-food Animal-based Versus Plant-based Protein Rich Meal on Muscle Protein Synthesis N/A
Not yet recruiting NCT06435637 - Effects of Ingesting Multiple Boluses of Collagen on Muscle & Skin Connective Protein Synthesis in Vivo in Humans N/A
Recruiting NCT04232254 - Defining Beef and Meal Frequency as Key Components of a Healthy Eating Pattern for Muscle Health and Wellbeing N/A
Completed NCT04981652 - The Effect of Whole Milk to Improve Muscle Health in Older Women N/A
Completed NCT02282566 - Effect of Protein-nutrition Beverages on Muscle Protein Synthesis in Women N/A
Completed NCT01885429 - Effect of Supplementing a Mixed Macronutrient Beverage With Graded Doses of Leucine on Myofibrillar Protein Synthesis N/A
Completed NCT05178732 - The Effect of Menstrual Cycle Phase and a Protein-polyphenol Drink on Muscle Protein Synthesis N/A