Physiological Constraints Associated With Trail Running

Muscle Fatigue Clinical Trial

— UT4M2018  

Official title:

Physiological Constraints Associated With Trail Running

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03712592
• Other study ID #: 38RC18.096
• Status: Completed
• Phase: N/A
• Start date: July 23, 2018
• Est. completion date: September 5, 2018

Study information

• Verified date: October 2018
• Source: University Hospital, Grenoble
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The practice of mountain running or "trail" is in full development in France and elsewhere in the world. This sporting practice associates specific physiological constraints related in particular to the duration of the efforts made (several hours) and to the ground (important elevation, technical ground, average altitude). Some studies have allowed the last 10 years to initiate the exploration of the physiological consequences of this type of practice, especially from a muscular point of view. However, some important questions remain to be clarified such as the impact of these sports events on fatigue and muscle recovery, cardiovascular, energy and water balance disturbances caused, induced sleep changes and the kinetics of recovery of the various parameters. . These elements remain in particular to be studied in very different racing contexts as currently developed by the organizers, namely race in one stage from long to very long distances (40 to 160 km) and race in stages (4 days, 4 x 40 km) as encountered in the Grenoble UT4M race (Ultra Tour des 4 Massifs).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 83
• Est. completion date: September 5, 2018
• Est. primary completion date: August 23, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 55 Years

Eligibility

Inclusion Criteria:

• Man or woman

• 18-55 years

• Absence of chronic cardiovascular, respiratory, metabolic or neuromuscular disease

• > 3 years of trail running (at least 1 race> 40 km / year completed and a race> 100 km completed (trail group 160 km)

• Medical certificate of no contraindication to the practice of the trail

• Subjects available in Grenoble before and within 15 days after the race

• Subjects affiliated to a social security scheme

• Subjects able to sign informed consent.

Exclusion Criteria:

• Cardiorespiratory, metabolic and neurological diseases

• Non-Echogenic Subjects

• Subjects with chronic sleep disorders

• Psychiatric pathologies or ATCD of behavioral disorders

• Persons refusing to sign the information sheet and the participation agreement,

• persons under guardianship or not subject to a social security scheme,

• Pregnant woman, parturient, breastfeeding mother

• Person deprived of liberty by judicial or administrative decision,

• Person subject to a legal protection measure, who can not be included in clinical trials.

Related Conditions & MeSH terms

• Fatigue
• Muscle Fatigue

Intervention

Other:
• Pre and post running evaluations
Each visit will include a series of neuromuscular, cardiovascular, blood glucose and body composition evaluations will be performed. The subjects will provide some information about their muscular pain and their food and water intake. Finally, for the study of sleep that only concerns participants in the 4x40 km race, a home sleep registration banner will be given to each participant of the event step by step at the arrival of each stage in order to study sleep the next night as well as 2 nights after the arrival of the last stage.

Locations

Country	Name	City	State
France	CHU Grenoble-Alpes	Grenoble

Sponsors (2)

Lead Sponsor	Collaborator
University Hospital, Grenoble	University Grenoble Alps

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Quantification of the level of ankle extensors fatigue induced by trail	Pre-post-force decrease in muscle contractility of ankle extensors assessed by neurostimulation	one month and 12 days
Primary	Quantification of the level of knee extensors fatigue induced by trail	Pre-post-force decrease in muscle contractility of knee extensors assessed by neurostimulation	one month and 12 days
Primary	Quantification of the level of ankle extensors fatigue induced by trail	Pre-post-force decrease in muscle contractility of infarction assessed by echocardiography	one month and 12 days