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Multiple Trauma clinical trials

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NCT ID: NCT05630222 Completed - Multiple Trauma Clinical Trials

Evaluation of Effect of Intravenous Morphine vs Intravenous Ibuprofen and Acetaminophen vs Intravenous Ibuprofen

Start date: March 15, 2022
Phase: Phase 3
Study type: Interventional

Pain is an inseparable symptom of fractures and is the most important and common symptom that brings patients to medical centers; Therefore, paying attention to pain and its control is very important in the examination and treatment of fractures, and painkillers are usually needed for effective pain control. About 70-90% of the patients who go to the emergency room due to injuries have organ injuries. Among these patients, those who suffer from fractures endure severe pain, and since only 10% of patients have open fractures, the pain management of patients with closed fractures is particularly important. Various medicinal compounds have been used so far to control the pain of fractured patients, including opioid compounds such as morphine, non-steroidal anti-inflammatory drugs such as ibuprofen and acetaminophen. Opioids are the main drug class for pain control in fractures, but since they have significant side effects, various studies have been conducted in the field of comparing the anti-inflammatory effect of different drugs in fractures, and the effect of various combinations compared to opioids has been investigated. Non-steroidal anti-inflammatories are always considered as an alternative to opioids and acetaminophen has also been considered to reduce the dosage of opioids, so in this study the effect of three combinations of intravenous morphine and ibuprofen plus intravenous acetaminophen and intravenous ibuprofen on pain levels in patients with a closed limb fracture will be investigated. This study is a blind randomized clinical trial, which investigates and compares the effect of intravenous morphine (Daropakhsh Company) with intravenous ibuprofen (Caspian Taamin Company) and intravenous acetaminophen (Caspian Taamin Company) with intravenous ibuprofen (Caspian Taamin Company) in reducing the pain of patients with closed limb fractures. The population investigated in this study will include all patients referred to the emergency room of Al-Zahra and Ayatollah Kashani educational centers in Isfahan city in 2022-2023.

NCT ID: NCT05617404 Completed - Respiratory Failure Clinical Trials

Blunt Thoracic Trauma: Definition of a Standard Operating Procedure

Start date: February 1, 2020
Phase:
Study type: Observational

Rib fractures are the most frequent injury after blunt thoracic trauma. It is very important to choose the most appropriate interventions to prevent complications. But who will benefit most of those interventions remains a challenge. This study analyses the correlation between chest X-Ray and CT scan. We also analyse different scores to predict respiratory failure.

NCT ID: NCT05221476 Completed - Clinical trials for Comorbidities and Coexisting Conditions

Red Blood Cell Distribution Width and Charlson Comorbidity Indeces in the Frail Polytraumatized Patient.

Start date: January 2012
Phase:
Study type: Observational

In this study patients who were admitted to our hospital with critical injuries were enrolled retrospectively from January 2012 to December 2015. Patients with an ISS>16 points, an AIS >3 in one body region and at least 2 different body regions affected were included. RDW values on admission as well as preexisting comorbidities were evaluated.

NCT ID: NCT05175872 Completed - Trauma Injury Clinical Trials

Factors Affecting Mortality and Morbidity in Trauma Patients Followed in Intensive Care Unit

trauma
Start date: October 14, 2019
Phase:
Study type: Observational

In this study, the demographic and clinical characteristics of trauma patients followed up in the Intensive Care Unit of the Anesthesiology and Reanimation Clinic of the Health Sciences University Okmeydanı Training and Research Hospital for a 2-year period were evaluated prospectively to determine the morbidity and mortality rates and to determine the factors affecting these rates. data.

NCT ID: NCT05074095 Completed - Polytrauma Clinical Trials

Analysis of Urogenital Injuries in Polytraumatized Patients

Start date: January 1, 2016
Phase:
Study type: Observational

Urogenital injuries occur in approximately 5-10 % of all severly injured patients. The literature lacks a thorough investigation into the mechanisms of trauma, the analysis of the whole urogenital tract and especially the correlation of thoracic and lumbar spine and pelvic injuries with urogenital injuries. The goal of this study is to provide a thorough investigation into these primary end points in a multicenter study of university hospitals in Germany.

NCT ID: NCT04723992 Completed - Polytrauma Clinical Trials

25-Year Experience With Polytraumatized Patients in a Level 1 Trauma Center

Start date: January 1992
Phase:
Study type: Observational

In this study patients who were admitted to our hospital with critical injuries were enrolled retrospectively from January 1992 to December 2019. Patients with an ISS>16 points, an AIS >3 in one body region and at least 2 different body regions affected were included. Possible prognostic factors were evaluated.

NCT ID: NCT04683094 Completed - Sepsis Clinical Trials

Comparative Study for the Validity of Various Severity Scoring System

Start date: April 1, 2020
Phase:
Study type: Observational

Scoring systems for use in intensive care unit (ICU) patients have been introduced and developed over the last 30 years. They allow an assessment of the severity of disease and provide an estimate of in-hospital mortality

NCT ID: NCT04505293 Completed - Head Trauma Clinical Trials

Assessment of InfraScanner 2000™ in Detecting Subdural and Epidural Hematomas

Start date: October 5, 2021
Phase: N/A
Study type: Interventional

The goal of this study is to determine the sensitivity, specificity, and positive and negative predictive values of the a portable near-infrared-based device (portable NIR-based device), the InfraScanner 2000™, to detect intracranial hematomas (epidural hematomas (EDH) and/or subdural hematomas (SDH)) in patients hospitalized at Mbarara Regional Referral Hospital (MRRH) who have sustained or who are suspected to have sustained head trauma.

NCT ID: NCT04414800 Completed - Pain, Acute Clinical Trials

Intranasal Ketamine Versus Intranasal Fentanyl

Start date: April 1, 2017
Phase: Phase 3
Study type: Interventional

Abstract Background: Given the inadequate control of pain in patients with injury that refer to the emergency departments, the rapid onset of action of intranasal administration in pain management, and the avoidance of administering opioid medications, the present study aimed at evaluating the effect of intranasal ketamine versus intranasal fentanyl on pain management in isolated traumatic patients Materials and Methods: The current study was performed on 125 patients that were divided into the following three groups: control group (n = 41), 1 mg/kg intranasal ketamine group (n = 40), and 1μg/kg intranasal fentanyl group (n = 44). Then pain scores, HR, RR, BP, and SaO2 were recorded at baseline, 5, 10, 15, 30, and 40 minutes after the intervention.

NCT ID: NCT04410952 Completed - Polytrauma Clinical Trials

Pelvic Binder vs. Pelvic C-clamp for Bleeding Control

Start date: January 7, 2020
Phase:
Study type: Observational

Pelvic ring fractures carry a high risk for severe bleeding. Expecially bleeding from the posterior ring might result in a fatal course. Different types of external emergency stabilization (EES) are available for the posterior pelvic ring, namely the non-invasive pelvic binder or the invasive pelvic c-clamp. Which stabilization technique is superior, has not been investigated yet.