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Multiple System Atrophy clinical trials

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NCT ID: NCT05274568 Recruiting - Parkinson Disease Clinical Trials

Proof of Mechanism Study to Evaluate Binding of Alfa-synuclein

Start date: January 31, 2022
Phase: Phase 1
Study type: Interventional

The overall goal of this protocol is to: Evaluate [18F]UCB-2897 as an α-synuclein targeted radiopharmaceutical. The primary objective is: • Confirm a specific α -synuclein signal with [18F]UCB-2897 in participants with PD and/or MSA relative to healthy volunteers Secondary and exploratory objectives are: - Determine the safety and tolerability of microdose [18F]UCB-2897 - Evaluate preliminary dosimetry of [18F]UCB-2897 Additional exploratory objectives are: - Determine the pharmacokinetics / metabolism of [18F]UCB-2897 - Determine the optimal imaging protocol for [18F]UCB-2897

NCT ID: NCT05238545 Recruiting - Parkinson Disease Clinical Trials

The Effect of Gluten-free Diet on Parkinsonism

GFREEPARK
Start date: October 1, 2021
Phase: N/A
Study type: Interventional

Recent data suggest that the brain-gut axis, chronic intestinal inflammation and microbiome may contribute to the pathogenesis of neurodegenerative diseases with alfa-synucleinopathy, which include Parkinson's disease (PD) and Multiple system atrophy (MSA). Environmental factors e.g. diets, microbiome, metabolites and immune mechanisms may play important role in pathogenesis of these diseases. In the human arm of this project, the investigators will address effects of an anti-inflammatory gluten-free diet (GFD) on motor and non-motor symptoms as well as its effects on immune and metabolomic characteristics in patients with PD and MSA. In the mouse arm, the investigations will focus on the effects of GFD in chronic MPTP-induced mouse model of PD in various settings (e.g. in young or aged animals, with respect to the lengths of exposure to GFD). The chronic MPTP model will be used to assess the effects of GFD on adaptive and immune characteristics, and metabolic signatures. Using germ-free animals, the microbiome-dependency of the GFD-mediated effects may be determined. The anti-inflammatory gluten-free diet and its related mechanisms represent novel, promising and relatively straightforward approach in a search to improve symptoms of PD as well as MSA or even in their prevention.

NCT ID: NCT05222386 Recruiting - Parkinson Disease Clinical Trials

Community Outreach for Palliative Engagement -- Parkinson Disease

COPE-PD
Start date: April 26, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to learn more about the effectiveness of palliative care training for community physicians and telemedicine support services for patients and carepartners with Parkinson's disease and Lewy Body Dementia (LBD) or related conditions and their care partners. Palliative care is a treatment approach focused on improving quality of life by relieving suffering in the areas of physical symptoms such as pain, psychiatric symptoms such as depression, psychosocial issues and spiritual needs. Telemedicine is the use of technology that allows participants to interact with a health care provider without being physically near the provider.

NCT ID: NCT05197816 Recruiting - Clinical trials for MSA - Multiple System Atrophy

MotIoN aDaptive Deep Brain Stimulation for MSA

MINDS
Start date: December 3, 2021
Phase: N/A
Study type: Interventional

Patients routinely undergo deep brain stimulation (DBS) for treatment of symptoms related to neurodegenerative conditions, most commonly Parkinson's disease. In the Investigator's experience, and published evidence shows, that stimulation has effects on the autonomic nervous system. In patients undergoing therapeutic DBS for a particular subtype of Parkinsonism (Multiple System Atrophy), the effects on autonomic parameters such as blood pressure and bladder symptoms has been shown to be improved by the investigators (unpublished data). In this current study, the investigators plan to use a novel technique of adaptive DBS in order to provide stimulation dependent on patient physiological or positional factors. This is with the aim of making stimulation more responsive and patient-specific.

NCT ID: NCT05171205 Recruiting - Clinical trials for Multiple System Atrophy

Spinal Cord Stimulation for Multiple System Atrophy

Start date: May 1, 2021
Phase: N/A
Study type: Interventional

Spinal Cord Stimulation (SCS) is a newly emerged neuromodulation technique in recent years. It is now a mature technique in the treatment of chronic pain and is generally accepted by patients because of its non-destructive and reversible nature, few complications, no side effects, and avoidance of unnecessary surgical procedures. Combining the results of previous studies and the group's previous research, this study first proposes an innovative treatment protocol for multiple system atrophy with SCS. We intend to conduct a prospective single-center open clinical trial to evaluate the improvement of orthostatic hypotension, urinary retention, sleep disturbance, dysarthria, and dysphagia in multiple system atrophy (MSA) patients before and after SCS treatment, and shed new light on the treatment for MSA.

NCT ID: NCT05167721 Recruiting - Clinical trials for Multiple System Atrophy

Randomized Double-Blind Placebo-Controlled Adaptive Design Trial Of Intrathecally Administered Autologous Mesenchymal Stem Cells In Multiple System Atrophy

Start date: December 15, 2021
Phase: Phase 2
Study type: Interventional

Multiple system atrophy (MSA) is a rare, rapidly progressive, and invariably fatal neurological condition characterized by autonomic failure, parkinsonism, and/or ataxia. There is no available treatment to slow or halt disease progression. The purpose of this study is to assess optimal dosing frequency, effectiveness and safety of adipose-derived autologous mesenchymal stem cells delivered into the spinal fluid of patients with MSA. Funding source: FDA Office of Orphan Product Development (OOPD), Mayo Clinic Executive Dean for Research Transformational Award, Mayo Clinic Regenerative Medicine, and Mayo Clinic Department of Neurology.

NCT ID: NCT05139342 Recruiting - Parkinson Disease Clinical Trials

Evaluation of the Efficacy of a Two-week EMST on Dysphagia in Parkinsonian Patients

EMST-PS
Start date: November 15, 2021
Phase: N/A
Study type: Interventional

This is an interventional therapy study designed to evaluate the efficacy of a two-week intervention, i.e. training with a specialized exhalation training device (called expiratory muscle strength training; EMST150 or EMST75; Aspire Products, Gainsville, FL) on swallowing function in patients with neurodegenerative Parkinsonian disorders. This study involves a routine endoscopic evaluation of swallowing (FEES) to diagnose dysphagia before and after the intervention. Between the two FEES, a two-week exhalation training program takes place, which the patients perform independently following instructions from a speech and lanuage pathologist. In addition demographic and disease-specific data and two questionnaires (Swallowing Disturbance Questionnaire for Parkinson's disease patients, SDQ-PD, and Swallowing specific Quality Of Life Questionnaire SWAL-QoL) are recorded.

NCT ID: NCT05121012 Recruiting - Clinical trials for Multiple System Atrophy

Synaptic Loss in Multiple System Atrophy

Start date: September 1, 2021
Phase:
Study type: Observational

In this study the investigators would like to investigate the degree of damage of the synapses, an important part of the neurons vital for the communications between neurons, in Multiple System Atrophy (MSA).

NCT ID: NCT04965922 Recruiting - Clinical trials for Multiple System Atrophy

Quality of Life of Caregivers and Patients Suffering From Multiple System Atrophy

QUA2-AMS
Start date: July 1, 2021
Phase: N/A
Study type: Interventional

Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disorder that cause as other neurodegenerative diseases profound declines in functioning and thus, require caregiving for assistance with daily living. The aim of the study is to evaluate the effect of a multimodal intervention as proposed by the NYU Caregiver Counseling and Support Intervention (NYUCI) on the quality of life of patients and their caregivers.

NCT ID: NCT04920552 Recruiting - Parkinson Disease Clinical Trials

Abdominal Binders to Treat Orthostatic Hypotension in Parkinsonian Syndromes

ABOH-PS
Start date: May 17, 2021
Phase: N/A
Study type: Interventional

The purpose of the present clinical trial is to determine whether the use of an elastic abdominal binder is effective in the non-pharmacological management of symptomatic, neurogenic orthostatic hypotension (OH) in individuals suffering from Parkinson's disease (PD) or Parkinson variant multiple system atrophy (MSA-P).