Ketamine for MS Fatigue

Status Recruiting

Clinical Trial Summary

The purpose of this study is to see whether using ketamine to increase glutamate in the prefrontal cortex can reduce Multiple Sclerosis (MS) related fatigue. The investigator proposes a prospective, crossover, randomized, placebo-controlled study to assess the efficacy and safety of low, single dose Ketamine, to assess its efficacy and safety in patients with MS-related fatigue.

Clinical Trial Description

The study treatment is designed in two 28-day cycles: for each cycle, participants will receive study infusion on Day 1 and complete follow-up visits during Days 7 and 28. Participants are randomized 1:1 to receive either ketamine (active treatment) or saline solution (placebo treatment) for their first infusion. They will not be blinded to their study assignment: the study doctor will disclose their assigned treatment group. After their first infusion cycle, participents will crossover to the other treatment group. Worded differently, if a participant received ketamine during their first infusion, they will receive placebo treatment during their second infusion. Conversely, if a participant received saline treatment during their first infusion, they will receive ketamine during their second infusion. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06064162
Study type	Interventional
Source	Alta Bates Summit Medical Center
Contact	Deepak Soneji, MD
Phone	510.204.8140
Email	Deepak.Soneji@sutterhealth.org
Status	Recruiting
Phase	Early Phase 1
Start date	December 5, 2023
Completion date	December 2025

View Details

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