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RIPC on Activity, Fatigue and Gait in MS — MSIPC-2  

Multiple Sclerosis Clinical Trial

Official title:
Role of Remote Ischaemic Preconditioning on Activity, Fatigue and Gait in People With Multiple Sclerosis.

Clinical Trial Summary

This study evaluates whether Remote Ischaemic Preconditioning (RIPC) can improve activity, gait and fatigue in people with Multiple Sclerosis. Half the participants will receive RIPC, the other half will receive a sham treatment.

Clinical Trial Description

Regular physical activity has been shown to improve physical fitness, fatigue, quality of life, and reduce the progression of disability in people with multiple sclerosis (MS). However, people with MS are less physically active than others. This is partly due to poor exercise tolerance and fatigue. Remote Ischemic preconditioning (RIPC) is the exposure of a limb to brief periods of circulatory occlusion and reperfusion by inflating pressure cuffs around arms or legs to above systolic pressures (mmHg), to protect organs against ischaemic injury. RIPC has been shown to improve exercise performance and delay fatigue in athletes. However, there is little to no research examining the effect of RIPC on walking or exercise performance in MS patients. The aim of this trial is to assess whether RIPC can improve activity, gait and reduce fatigue in people with MS. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03967106
Study type Interventional
Source Sheffield Teaching Hospitals NHS Foundation Trust
Contact
Status Completed
Phase N/A
Start date August 19, 2019
Completion date March 31, 2023
View Details
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