Multiple Sclerosis Clinical Trial
Official title:
Neurophysiological, Dynamometric, Functional and Clinical Assessment of the Cross-Training Effect in Patients With Multiple Sclerosis
The purpose of this study is to determine whether, in patients with multiple sclerosis presenting with marked asymmetry of strength, training the less-affected limb with a Cross-Training approach may induce a meaningful transfer of strength with neurophysiological, functional and clinical correlates, to the contralateral, more-impaired limb.
Muscle weakness is a major disability that is responsible for deeply reducing the overall
quality of life (QoL) of patients with Multiple Sclerosis (MS). Research has shown that
strength training (ST) has a significant positive effect on the performance of daily living
activities in people with MS, resulting in an increased QoL. Several ST methods are
currently employed for reducing strength impairment in MS but no one regimen has been
portrayed as superior to others. When strength impairment is prominently lateralized to one
limb, training is commonly addressed to the weaker side in order to balance the deficit.
However, such ST may not always be applicable to a severely weakened limb that is too
compromised to sustain it. For these selected patients we hypothesize that training the less
affected limb with a Cross Training (CT) approach may overcome the problem, also avoiding
patients' frustration and potential withdrawals from rehabilitation programs.
Aim of this project is to investigate and compare in two groups of selected MS patients,
with a marked asymmetry of strength, the effects induced on dynamometric,
neurophysiological, functional and clinical outcomes by a CT of the less-impaired leg (CT
group) compared to a ST of the more-impaired leg (ST group). In order to make comparisons
with a population which is not exposed to the condition MS, a third group composed of
healthy subjects will also be included in the study.
The research plan will be articulated in 5 phases (recruitment, baseline assessment, 6
week-intervention phase, post-intervention assessment and follow up at 12 weeks).
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