Multiple Sclerosis Clinical Trial
Official title:
Combined Clinical, Immunological and Virological Assessment of Patients With Multiple Sclerosis (MS)
Verified date | February 1, 2010 |
Source | National Institutes of Health Clinical Center (CC) |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Multiple sclerosis (MS) is a disease of the nervous system. The exact cause of MS is unknown,
but it is believed to be an autoimmune condition. Autoimmune conditions are diseases that
cause the body's immune system and natural defenses to attack healthy cells. In the case of
MS, the immune system begins attacking myelin, the cells that make up the sheath covering
nerves. Without myelin, nerves are unable to transmit signals effectively and symptoms occur.
This study is directed toward a better understanding of the cause of Multiple Sclerosis (MS).
Researchers will evaluate patients with a tentative diagnosis of MS or other neurological
diseases possibly caused by a immunological reaction. Patients will undergo a series of three
MRIs, taken once a month for three months and submit blood samples for immunological studies.
Status | Completed |
Enrollment | 1388 |
Est. completion date | February 1, 2010 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 75 Years |
Eligibility |
- INCLUSION CRITERIA: Diagnosis of possible MS. Age between 18 and 75. EXCLUSION CRITERIA: Clinically significant medical condition other than MS that could cause neurological dysfunction. Currently enrolled in an experimental study. Medical contraindication for MRI. Psychological contraindications for MRI. Unable to provide informed consent. |
Country | Name | City | State |
---|---|---|---|
United States | National Institutes of Health Clinical Center, 9000 Rockville Pike | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Institute of Neurological Disorders and Stroke (NINDS) |
United States,
Alexander EL, Beall SS, Gordon B, Selnes OA, Yannakakis GD, Patronas N, Provost TT, McFarland HF. Magnetic resonance imaging of cerebral lesions in patients with the Sjögren syndrome. Ann Intern Med. 1988 Jun;108(6):815-23. — View Citation
Beall SS, Concannon P, Charmley P, McFarland HF, Gatti RA, Hood LE, McFarlin DE, Biddison WE. The germline repertoire of T cell receptor beta-chain genes in patients with chronic progressive multiple sclerosis. J Neuroimmunol. 1989 Jan;21(1):59-66. — View Citation
Martin R, McFarland HF, McFarlin DE. Immunological aspects of demyelinating diseases. Annu Rev Immunol. 1992;10:153-87. Review. — View Citation
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