Multiple Sclerosis Clinical Trial
— PROMOTEOfficial title:
Prospective Investigation of Multiple Sclerosis in the Three Rivers Region
NCT number | NCT02994121 |
Other study ID # | STUDY19080007 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | December 2016 |
Est. completion date | January 2047 |
In this longitudinal prospective natural history study of multiple sclerosis (MS), the overarching goal is to understand the factors that influence individual variation in disease trajectory and treatment response and pave the way for realizing precision medicine in MS. Because MS is a chronic neurological disorder, this observational cohort study will span a 30-year time frame.
Status | Recruiting |
Enrollment | 7500 |
Est. completion date | January 2047 |
Est. primary completion date | January 2047 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 7 Years and older |
Eligibility | Inclusion Criteria: - Inclusion criteria for MS patients include: 1. willing and able to give consent 2. age 7 years or older 3. diagnosis of multiple sclerosis or related disorders, including a first central nervous system demyelinating episode with a positive MRI scan or abnormal MRI scans characteristic of MS but no clinical symptoms of the disease - For healthy controls: 1. Age 7 years or older 2. Willing and able to provide consent (for >=18 years) or assent with permission from at least one of the child's parents (for <18 years) 3. No known personal history of multiple sclerosis or related disorders 4. No other chronic diseases 5. Family members, unrelated household controls, or controls from the general population could be eligible There is no exclusion criteria. |
Country | Name | City | State |
---|---|---|---|
United States | University of Pittsburgh | Pittsburgh | Pennsylvania |
Lead Sponsor | Collaborator |
---|---|
University of Pittsburgh |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Establish a prospective cohort of well-characterized MS patients and controls | For this longitudinal prospective observational study, we will establish a prospective cohort of well-characterized MS patients and controls (2:1). | within 30 years | |
Primary | Investigate the predictors of the variations in disease trajectory and treatment response | Understanding the factors that influence disease trajectory and treatment response will pave the way to realize precision medicine in delivering individualized MS care. | within 30 years |
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