Multiple Myeloma Clinical Trial
Official title:
Phase II Trial of Adjuvant Cellular Immunotherapy for High-Risk Hematologic Malignancy After Reduced Intensity Allogeneic Stem Cell Transplantation
The purpose of this study is to determine whether a reduced intensity conditioning regimen for stem cell transplant with donor cells will allow the donor cells to be effective without causing health problems.
In this research study patients will receive dosages of chemotherapy that are lower than the
usual dosages. The study will determine whether a shorter duration of immunosuppression will
permit the donor cells to be effective against the cancer without causing more severe GVHD
(Graft Versus Host Disease). Also to be determined is whether the patient's cancer can be
prevented from relapsing after blood stem cell transplant by using prophylactic treatment,
giving a donor leukocyte infusion BEFORE a relapse happens.
In this research study samples of blood and bone marrow will be analyzed. These samples will
be examined to study the cellular production of inflammatory cytokine levels in attempt to
be able to predict which patients will have complications like GVHD or relapse.
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Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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