MRSA Clinical Trial - Retapamulin as a Decolonizing Agent for MRSA

Status Completed

Clinical Trial Summary

The purpose of this study is to investigate the efficacy of retapamulin to reduce carriage of MRSA via a randomized, double-blind, placebo-controlled clinical study testing retapamulin among patients with confirmed mupirocin-resistant nasal and/or rectal MRSA colonization. The sample size will include 27 subjects in each of the two arms of the study (retapamulin versus placebo) for a total of 54 subjects. Participants who are found to be nasal and/or rectal colonized with MRSA will be randomized to receive either retapamulin or placebo applied nasally and rectally for a total of 5 days. Nasal and rectal swabs will be collected at pre-defined time points during study duration (screening swab, swab one week after completion of topical therapy, swab 4 weeks after completion of topical therapy) to assess MRSA colonization status. The colonization rates of both groups will be assessed via Fisher's Exact Test.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

MRSA

Clinical Trial Details

NCT number	NCT03304873
Study type	Interventional
Source	NYU Langone Health
Contact
Status	Completed
Phase	Phase 3
Start date	December 1, 2017
Completion date	March 18, 2019

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